Department of Cardiothoracic Surgery, Weill Cornell Medical Center, 535 E 68th Street, New York, NY, 10065, USA.
Department of Cardiothoracic Surgery, Weill Cornell Medical Center, 535 E 68th Street, New York, NY, 10065, USA.
Int J Surg. 2020 May;77:25-29. doi: 10.1016/j.ijsu.2020.03.023. Epub 2020 Mar 19.
Surgical animal models are used in pre-clinical scientific studies. To date there has not been an analysis of how effective these data are when translated to human/clinical research. In this retrospective review, we evaluate the impact of studies using surgical animal models on human/clinical research through study-level analysis of citations.
The top two ranking clinical journals based on impact factor for the top ten surgical specialties were identified and a search was run on PubMed to identify studies using surgical animal models published in the years 2007 and 2008. The translation to human/clinical research of each study was evaluated by analyzing the frequency of citation in human studies over the ten years following publication. Regression was used to identify predictors of citation in human/clinical research.
411 animal studies using surgical models were identified. Over the course of the 10 years following publication the original animal studies were cited 6063 times, with 1300 (21.4%) citations in human/clinical studies and 4763 (78.6%) in animal/basic science studies. The median number of citations in human/clinical research was 1 (IQR 0-5). Regression showed an association between citation in human/clinical research and the use of porcine models and the specialties of general surgery, oral and maxillofacial surgery, orthopedic surgery, transplant, and plastic surgery.
The use of animal models in surgical research shows poor translation to human/clinical research. Alternative surgical models should urgently be explored.
外科动物模型被用于临床前科学研究。迄今为止，还没有分析这些数据在转化为人类/临床研究时的有效性。在这项回顾性研究中，我们通过对引用的研究水平分析，评估了使用外科动物模型的研究对人类/临床研究的影响。
确定了基于影响因子排名前两位的十大外科专业临床期刊，并在 PubMed 上搜索了 2007 年和 2008 年发表的使用外科动物模型的研究。通过分析发表后十年内人类研究的引用频率，评估了每一项研究对人类/临床研究的转化。采用回归分析确定人类/临床研究引用的预测因素。
共确定了 411 项使用外科模型的动物研究。在发表后的 10 年中，原始动物研究共被引用 6063 次，其中 1300 次（21.4%）在人类/临床研究中被引用，4763 次（78.6%）在动物/基础科学研究中被引用。人类/临床研究中引用的中位数为 1（IQR 0-5）。回归分析显示，在人类/临床研究中的引用与使用猪模型以及普通外科、口腔颌面外科、骨科、移植和整形外科学科有关。
外科研究中使用动物模型与人类/临床研究的相关性较差。迫切需要探索替代的外科模型。
