Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences, Northwest University, 229 Taibai North Road, Xi'an 710069, China.
Department of Cardiology, Xijing Hospital, The Fourth Military Medical University, 127 Changle West Road, Xi'an 710032, China.
J Mol Biol. 2020 May 1;432(10):3177-3190. doi: 10.1016/j.jmb.2020.03.010. Epub 2020 Mar 18.
As central components of the Hippo signaling pathway in mammals, the mammalian sterile 20-like kinase 1 (MST1) and MST2 protein kinases regulate cell proliferation, survival, and death and are involved in the homeostasis of many tissues. Recent studies have elucidated the roles of MST1 and MST2 in the nervous system and immune system, particularly in neurological disorders, which are influenced by aging. In this review, we provide a comprehensive overview of these research areas. First, the activation mechanisms and roles of MST1 and MST2 in neurons, non-neuronal cells, and immune cells are introduced. The roles of MST1 and MST2 in neurological disorders, including brain tumors, cerebrovascular diseases, neurodegenerative disorders, and neuromuscular disorders, are then presented. Finally, the existing obstacles for further research are discussed. Collectively, the information compiled herein provides a common framework for the function of MST1 and MST2 in the nervous system, should contribute to the design of further experiments, and sheds light on potential treatments for aging associated neurological disorders.
作为哺乳动物 Hippo 信号通路的核心组成部分，哺乳动物 sterile 20-like 激酶 1（MST1）和 MST2 蛋白激酶调节细胞增殖、存活和死亡，并参与许多组织的动态平衡。最近的研究阐明了 MST1 和 MST2 在神经系统和免疫系统中的作用，特别是在受衰老影响的神经退行性疾病中。在这篇综述中，我们全面概述了这些研究领域。首先，介绍了 MST1 和 MST2 在神经元、非神经元细胞和免疫细胞中的激活机制和作用。然后介绍了 MST1 和 MST2 在神经退行性疾病中的作用，包括脑肿瘤、脑血管疾病、神经退行性疾病和神经肌肉疾病。最后，讨论了进一步研究的现有障碍。总的来说，本文汇编的信息为 MST1 和 MST2 在神经系统中的功能提供了一个共同的框架，应该有助于进一步实验的设计，并为与衰老相关的神经退行性疾病的潜在治疗方法提供了思路。
