Department of Biomolecular Sciences, Kingston University London, Kingston-upon-Thames KT1 2EE, UK.
Department of Chemistry and Pharmaceutical Sciences, Kingston University London, Kingston-upon-Thames KT1 2EE, UK.
Cells. 2021 Nov 12;10(11):3144. doi: 10.3390/cells10113144.
The activation of microglia, the inflammatory cells of the central nervous system (CNS), has been linked to the pathogenesis of Alzheimer's disease and other neurodegenerative diseases. How microglia sense the changing brain environment, in order to respond appropriately, is still being elucidated. Microglia are able to sense and respond to the mechanical properties of their microenvironment, and the physical and molecular pathways underlying this mechanosensing/mechanotransduction in microglia have recently been investigated. The Hippo pathway functions through mechanosensing and subsequent protein kinase cascades, and is critical for neuronal development and many other cellular processes. In this review, we examine evidence for the potential involvement of Hippo pathway components specifically in microglia in the pathogenesis of Alzheimer's disease. We suggest that the Hippo pathway is worth investigating as a mechanosensing pathway in microglia, and could be one potential therapeutic target pathway for preventing microglial-induced neurodegeneration in AD.
小胶质细胞是中枢神经系统（CNS）的炎症细胞，其激活与阿尔茨海默病和其他神经退行性疾病的发病机制有关。小胶质细胞如何感知不断变化的大脑环境，以便做出适当的反应，仍在研究中。小胶质细胞能够感知和响应其微环境的机械特性，并且最近已经研究了小胶质细胞中这种机械感知/机械转导的物理和分子途径。 Hippo 途径通过机械感知和随后的蛋白激酶级联反应发挥作用，对于神经元发育和许多其他细胞过程至关重要。在这篇综述中，我们研究了 Hippo 途径成分在阿尔茨海默病发病机制中小胶质细胞中的潜在作用的证据。我们认为 Hippo 途径作为小胶质细胞中的机械感知途径值得研究，并且可能是预防 AD 中小胶质细胞诱导的神经退行性变的潜在治疗靶点途径之一。
