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十年重建手术:头颈部游离组织移植的结果与展望。单中心机构的经验。

A decade of reconstructive surgery: outcome and perspectives of free tissue transfer in the head and neck. Experience of a single center institution.

作者信息

Spoerl Steffen, Schoedel Shlomo, Spanier Gerrit, Mueller Karolina, Meier Johannes K, Reichert Torsten E, Ettl Tobias

机构信息

Department of Cranio- and Maxillofacial Surgery, Hospital of the University of Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.

Centre for Clinical Studies, Hospital of the University of Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.

出版信息

Oral Maxillofac Surg. 2020 Jun;24(2):173-179. doi: 10.1007/s10006-020-00838-7. Epub 2020 Mar 20.

Abstract

PURPOSE

Free flaps have become the standard option in reconstructive surgery of the head and neck. Even though many authors have outlined the reliability of free transplants, there is an ongoing discussion about treatment options for patients bearing particular risks as previous irradiation treatment. In this analysis, we aim to address these patients with particular risk profiles by comparing different flap entity outcome parameters.

METHODS

We retrospectively analyzed a cohort of 494 patients who underwent flap surgery between 2009 and 2018 in our department. Focusing on free microvascular transplants, we additionally analyzed the pectoralis major myocutaneous flap as the most frequently used vascular pedicled flap. Data analysis was performed by uni- and multivariate statistics.

RESULTS

Overall flap success rate was 90%, with the radial forearm flap occurring to be most reliable (93%) in head and neck reconstruction. Previous radiation therapy (RT) and intraoperative revision of vascular anastomosis during primary surgery significantly resulted in impaired transplant outcome with a success rate of 91.8% (no RT) vs. 83.7% (RT), respectively. There was a negative linear correlation between incision to suture time and number of flaps per year (R = 0.67).

CONCLUSIONS

Preoperative radiation therapy and intraoperative revision of anastomosis significantly impair outcome of microvascular flaps in the head and neck and oral cavity, whereas patient's age is not a predictor of flap failure. Increasing case number and experience reduces time of flap surgery as well as rate of complications and flap failure.

摘要

目的

游离皮瓣已成为头颈部重建手术的标准选择。尽管许多作者已概述了游离移植的可靠性,但对于有特定风险(如既往接受过放射治疗)的患者的治疗选择仍在进行讨论。在本分析中,我们旨在通过比较不同皮瓣实体的结局参数来探讨这些具有特定风险特征的患者。

方法

我们回顾性分析了2009年至2018年在我科接受皮瓣手术的494例患者队列。聚焦于游离微血管移植,我们还分析了最常用的带血管蒂皮瓣——胸大肌肌皮瓣。通过单变量和多变量统计进行数据分析。

结果

总体皮瓣成功率为90%,前臂桡侧皮瓣在头颈部重建中最为可靠(93%)。既往放疗(RT)和初次手术时术中对血管吻合口的修复显著导致移植结局受损,成功率分别为91.8%(未放疗)和83.7%(放疗)。切开至缝合时间与每年皮瓣数量之间存在负线性相关(R = 0.67)。

结论

术前放疗和术中吻合口修复显著损害头颈部和口腔微血管皮瓣的结局,而患者年龄不是皮瓣失败的预测因素。增加病例数量和经验可减少皮瓣手术时间以及并发症和皮瓣失败率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9fb2/7230044/811ab669bbcd/10006_2020_838_Fig1_HTML.jpg

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