Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Physiology, Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
J Cell Physiol. 2020 Oct;235(10):6393-6403. doi: 10.1002/jcp.29639. Epub 2020 Mar 20.
Venous and arterial thrombosis are conditions that have a considerable burden if left untreated. The hypoxia-induced by the occluded vessel can disrupt the circulation of any organ, the cornerstone of treating thrombosis is rapid diagnosis and appropriate treatment. Diagnosis of thrombosis may be made by using laboratory tests or imaging techniques in individuals who have clinical manifestations of a thrombotic event. The use of serum micro ribonucleic acids (RNAs) has recently been applied to the diagnosis of thrombosis. These small RNA molecules are emerging as new diagnostic markers but have had very limited applications in vascular disease. Most of the articles provided various microRNAs with different levels of accuracy. However, there remains a lack of an appropriate panel of the most specific microRNA in the literature. The purpose of the present review was to summarize the existing data on the use of microRNAs as a diagnostic biomarker for venous thrombosis.
静脉和动脉血栓形成是未经治疗就会带来严重后果的疾病。阻塞血管引起的缺氧会破坏任何器官的循环，治疗血栓形成的基石是快速诊断和适当的治疗。对于有血栓形成事件临床表现的个体，可以通过实验室检查或影像学技术来诊断血栓形成。最近，血清微核糖核酸 (RNAs) 的应用已被用于血栓形成的诊断。这些小分子 RNA 作为新的诊断标志物正在出现，但在血管疾病中的应用非常有限。大多数文章都提供了不同准确性水平的各种 microRNAs。然而，文献中仍然缺乏最特异的 microRNA 的合适组合。本综述的目的是总结 microRNAs 作为静脉血栓形成诊断生物标志物的现有数据。
