Institute of Systems Biotechnology, Universität des Saarlandes, Germany.
Institute of Systems Biotechnology, Universität des Saarlandes, Germany.
Curr Opin Biotechnol. 2020 Oct;65:118-128. doi: 10.1016/j.copbio.2020.02.010. Epub 2020 Mar 18.
Extremolytes are small organic molecules, which protect cells under extreme, virtually inhabitable conditions. Their exceptional properties can be translated into health-promoting and therapeutic activities, which open an avenue of opportunities for the cosmetic, medical, and food industries. Supported by powerful approaches from systems and synthetic biology and systems metabolic engineering, the bio-industry becomes more and more attracted to exploit this 'goldmine'. In addition to the well-established flagship ectoine, several novel extremolytes have emerged in the past years and high-efficiency cell factories have been created for bio-based extremolyte production. Here, we review recent prominent examples and success stories in the field.
极端微生物适应物是小分子有机化合物，可保护细胞在极端、几乎无法生存的条件下存活。它们的特殊性质可以转化为促进健康和治疗活性，为化妆品、医学和食品行业开辟了机会。在系统和合成生物学以及系统代谢工程的强大方法的支持下，生物产业越来越倾向于利用这个“金矿”。除了成熟的标志性海藻糖外，近年来还出现了几种新型极端微生物适应物，并为生物基极端微生物适应物生产创建了高效细胞工厂。在这里，我们回顾了该领域最近的突出范例和成功案例。
