Barbosa Fabiano Timbó, Neto Olavo Barbosa de Oliveira, Barbosa Luciano Timbó, Andrade Raul Ribeiro de, Ribeiro Êurica Adélia Nogueira, Rodrigues Célio Fernando de Sousa
Universidade Federal de Alagoas, Maceió, AL, Brasil.
Universidade Federal de Alagoas, Maceió, AL, Brasil.
Braz J Anesthesiol. 2020 Jan-Feb;70(1):42-47. doi: 10.1016/j.bjan.2019.12.002. Epub 2020 Feb 19.
Magnesium sulphate has been used in anesthesia because it has relevant clinical features such as: analgesia, autonomic response control and muscle relaxation. Using the agent to establish adequate conditions for tracheal intubation remains controversial. The aim of the study was to compare the effectiveness of magnesium sulfate and rocuronium for rapid sequence tracheal intubation in adults.
Double blind, randomized, unicentric, prospective study assessed 68 patients, ASA 1 or 2, over 18 years, scheduled for appendectomy under general anesthesia. Patients were divided into two groups. GM patients received 50 mg.kgmagnesium sulfate and GR patients, 1 mg.kg rocuronium immediately before anesthesia induction. Arterial Blood Pressure (BP) and Heart Rate (HR) were measured in both groups at five times related to the administration of the drugs studied. The primary variable was the clinical status of tracheal intubation.
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GM was associated with no significant hemodynamic parameter change after injection. GM showed 85% (29/34) poor intubation clinical status, 15% (5/34) good, and 0% excellent (< 0.0001).
Magnesium sulfate did not provide adequate clinical status when compared to rocuronium at a dose of 50 mg.kg for rapid sequence intubation in adult patients.
硫酸镁已用于麻醉，因为它具有相关临床特性，如镇痛、自主反应控制和肌肉松弛。使用该药物为气管插管创造合适条件仍存在争议。本研究的目的是比较硫酸镁和罗库溴铵在成人快速顺序气管插管中的有效性。
双盲、随机、单中心、前瞻性研究评估了68例年龄超过18岁、ASA 1或2级、计划在全身麻醉下进行阑尾切除术的患者。患者分为两组。GM组患者在麻醉诱导前立即接受50mg/kg硫酸镁，GR组患者接受1mg/kg罗库溴铵。在与所研究药物给药相关的五个时间点测量两组患者的动脉血压（BP）和心率（HR）。主要变量是气管插管的临床状态。
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GM组注射后血流动力学参数无显著变化。GM组插管临床状态差的占85%（29/34），良好的占15%（5/34），优秀的占0%（<0.0001）。
在成人患者快速顺序插管中，与50mg/kg剂量的罗库溴铵相比，硫酸镁不能提供足够的临床状态。
