Ohyama Shoichiro, Hoshino Masatoshi, Takahashi Shinji, Hori Yusuke, Yabu Akito, Kobayashi Akio, Tsujio Tadao, Kotake Shiro, Nakamura Hiroaki
Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, Japan.
Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka, Japan.
J Orthop Sci. 2021 Jan;26(1):167-172. doi: 10.1016/j.jos.2020.02.006. Epub 2020 Mar 19.
Conditions of the elderly like sarcopenia, locomotive syndrome, and frailty have been attracting attention recently. However, the relationship of these 3 conditions and the difference in the magnitude of influence each has on deterioration in health status remain unclear. The purpose of this study was to investigate the prevalence and relationship of sarcopenia, locomotive syndrome, and frailty, and to clarify their influence on the dropout from cohort study due to deterioration in health status.
The 1st survey of the Shiraniwa Elderly Cohort (Shiraniwa) study was conducted in 2016. We examined 409 participants (aged ≥ 65 years; 164 males, 245 females) and assessed sarcopenia, locomotive syndrome, and frailty. Those who could not attend the 2nd survey (2017) due to deterioration in health status were defined as the Dropout group. We investigated the predictors of Dropout using multiple logistic regression analysis.
The prevalence of sarcopenia, locomotive syndrome stage 2, and frailty were 4.4%, 40.1%, and 14.2%, respectively; 89.7% of participants with frailty were also diagnosed with locomotive syndrome stage 2. From the results of the 2nd survey, 46 people were classified into the Dropout group. Independent predictors of the Dropout were locomotive syndrome stage 2 (adjusted odds ratio [OR]: 2.42, 95% confidence interval [CI]: 1.11-5.31) and frailty (adjusted OR: 3.37, 95%CI: 1.56-7.30).
Locomotive syndrome stage 2 was the most common condition in the elderly, and most people with frailty also had locomotive syndrome stage 2. Locomotive syndrome stage 2 and frailty independently influenced the dropout from cohort study due to deterioration in health status. These results suggest that screening for locomotive syndrome is useful for early detection of the elderly with a risk of deterioration in health status, and screening for frailty may contribute to detecting the elderly with higher risk of deterioration in health status.
近年来，老年人的肌肉减少症、运动机能综合征和衰弱等状况备受关注。然而，这三种状况之间的关系以及它们各自对健康状况恶化影响程度的差异仍不明确。本研究的目的是调查肌肉减少症、运动机能综合征和衰弱的患病率及关系，并阐明它们对因健康状况恶化而退出队列研究的影响。
白庭老人队列（白庭）研究的首次调查于2016年进行。我们对409名参与者（年龄≥65岁；男性164名，女性245名）进行了检查，并评估了肌肉减少症、运动机能综合征和衰弱情况。因健康状况恶化而无法参加第二次调查（2017年）的人被定义为退出组。我们使用多因素逻辑回归分析调查了退出的预测因素。
肌肉减少症、运动机能综合征2期和衰弱的患病率分别为4.4%、40.1%和14.2%；89.7%的衰弱参与者也被诊断为运动机能综合征2期。根据第二次调查结果，46人被归入退出组。退出的独立预测因素是运动机能综合征2期（调整后的优势比[OR]：2.42，95%置信区间[CI]：1.11 - 5.31）和衰弱（调整后的OR：3.37，95%CI：1.56 - 7.30）。
运动机能综合征2期是老年人中最常见的状况，大多数衰弱的人也患有运动机能综合征2期。运动机能综合征2期和衰弱独立影响因健康状况恶化而退出队列研究。这些结果表明，筛查运动机能综合征有助于早期发现有健康状况恶化风险的老年人，而筛查衰弱可能有助于检测出健康状况恶化风险更高的老年人。
