Eastern Virginia Medical School, Department of Obstetrics and Gynecology, Division of Female Pelvic Medicine and Reconstructive Surgery, 825 Fairfax Avenue, Suite 526, Norfolk, VA 23507-2007, USA.
University of Debrecen Faculty of Medicine, Department of Obstetrics and Gynecology, 4002 Debrecen, Pf. 400, Hungary.
Eur J Obstet Gynecol Reprod Biol. 2020 May;248:106-109. doi: 10.1016/j.ejogrb.2020.03.026. Epub 2020 Mar 12.
To investigate the effect of oral zinc supplementation on cervicovaginal lavage fluid (CVL) zinc level in pre and postmenopausal women.
A prospective interventional cohort study was carried out by the enrollment of twelve premenopausal and ten postmenopausal women without significant gynecological conditions. Women received daily oral supplementation with 30 mg of zinc for two weeks. Clinical and demographic variables were stored in a dedicated database. Vaginal Health Index was calculated, and vaginal cytology was obtained. CVL and serum samples were collected in a standardized fashion before and after completion of the oral supplementation. Zinc and copper levels were measured by inductively coupled plasma optical emission spectrometry. Paired t-test was used to compare the before and after treatment results.
Serum zinc levels increased significantly both in the pre and postmenopausal women (0.88 ± 0.17 vs. 1.06 ± 0.23, p < 0.01 and 0.83 ± 0.24 vs. 0.96 ± 0.33, p < 0.01) after two weeks of daily oral zinc supplementation. CVL zinc level was significantly higher in the premenopausal group compared to the postmenopausal group before and after supplementation (0.13 ± 0.05 vs. 0.06 ± 0.04, p < 0.01 and 0.10 ± 0.03 vs. 0.05 ± 0.01, p < 0.01). Zinc supplementation had no significant impact on the CVL zinc level in either group. Neither serum nor CVL copper levels were affected by the zinc supplementation. There was no significant correlation between serum and CVL zinc or copper levels.
Daily oral supplementation with 30 mg of zinc had no significant impact on CVL zinc level despite a significant rise in serum zinc level.
研究口服补锌对绝经前后妇女宫颈阴道灌洗液（CVL）锌水平的影响。
这是一项前瞻性干预队列研究，共纳入 12 名绝经前和 10 名绝经后无明显妇科疾病的女性。这些女性每天口服补充 30mg 锌，持续两周。临床和人口统计学变量存储在专用数据库中。计算阴道健康指数，并获取阴道细胞学检查。以标准化方式采集 CVL 和血清样本，分别在口服补充前后进行。采用电感耦合等离子体发射光谱法测量锌和铜水平。采用配对 t 检验比较治疗前后的结果。
绝经前和绝经后女性在两周的每日口服锌补充后，血清锌水平均显著升高（0.88±0.17 与 1.06±0.23，p<0.01；0.83±0.24 与 0.96±0.33，p<0.01）。CVL 锌水平在补充前后的绝经前组均显著高于绝经后组（0.13±0.05 与 0.06±0.04，p<0.01；0.10±0.03 与 0.05±0.01，p<0.01）。补锌对两组的 CVL 锌水平均无显著影响。血清和 CVL 铜水平均不受锌补充的影响。血清和 CVL 锌或铜水平之间无显著相关性。
尽管血清锌水平显著升高，但每日口服 30mg 锌对 CVL 锌水平没有显著影响。
