Department of Obstetrics and Gynecology, Sheba Medical Center at Tel Hashomer, Israel; Sackler school of medicine, Tel-Aviv University, Tel-Aviv, Israel.
ENT, Assuta Ashdod Medical Center, Israel.
Eur J Radiol. 2020 May;126:108937. doi: 10.1016/j.ejrad.2020.108937. Epub 2020 Mar 12.
Analyze fetal facial structures using MR imaging scans in an aim to establish normal biometrical measures of fetal nasal and mandibular structures for multiple gestational weeks, comprise nomograms and compare female and male fetuses.
A Historic cohort study of 255 fetal facial MR imaging scans was performed at a tertiary medical center during a 4-year period. Clinical data was collected from electronic medical charts. Length of septal height (SH), septal length (SL), Interocular Distance(IOD), maximal nasal length(MNL), mandibular vertebral length(MVL), antero-posterior diameter(APD), inferior facial angle(IFA) and biparietal diameter(BPD) were measured and compared with gender and gestational age (GA). Interrater and intrarater reliability was investigated.
Normal measures were established for each gestational age. We found that all parameters but IFA correlated with GA. Males had a longer SL, BPD and MNL while females had a wider IFA.
Novel facial biometric parameters that correlate with GA hold cardinal information for the prenatal evaluation of facial development and thus surface the need for additional research in order to asses these findings as radiologic markers for facial structural pathologies.
利用磁共振成像扫描分析胎儿面部结构，旨在建立多个妊娠周胎儿鼻和下颌结构的正常生物测量值，制定正常值图表，并比较女性和男性胎儿。
对一家三级医疗中心的 255 例胎儿面部磁共振成像扫描进行了历史性队列研究，历时 4 年。临床数据从电子病历中收集。测量并比较了鼻中隔高度（SH）、鼻中隔长度（SL）、眼距（IOD）、最大鼻长（MNL）、下颌椎体长度（MVL）、前后径（APD）、下面部角（IFA）和双顶间径（BPD）与性别和孕龄（GA）的关系。对观察者内和观察者间的可靠性进行了调查。
为每个孕龄建立了正常的测量值。我们发现除了 IFA 之外，所有参数都与 GA 相关。男性的 SL、BPD 和 MNL 较长，而女性的 IFA 较宽。
与 GA 相关的新型面部生物测量参数为面部发育的产前评估提供了重要信息，因此需要进一步研究以评估这些发现是否为面部结构病变的影像学标志物。
