Cang Zhengqiang, Cui Jiangbo, Pei Jiaomiao, Wang Zheng, Du Yichen, Mu Siqi, Dou Wenjie, Fan Xing, Zhang Xi, Li Yang
Department of Plastic and Reconstructive Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, China.
Department of Ultrasound Diagnosis, Qinhuang Hospital, Xi'an, China.
Front Pediatr. 2023 Apr 12;11:1161421. doi: 10.3389/fped.2023.1161421. eCollection 2023.
This systematic review aimed to analyze the characteristics of different diagnostic techniques for micrognathia, summarize the consistent diagnostic criteria of each technique, and provide a simple and convenient prenatal diagnosis strategy for micrognathia.
In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, the search was undertaken in three international databases (PubMed, Scopus, and Web of Science). The three reviewers assessed all papers and extracted the following variables: author's name and year of publication, country, study design, number of participants, gestational age, equipment for prenatal examination, biometric parameters related to micrognathia, main results.
A total of 25 articles included in the analysis. Nineteen articles described cross-sectional studies (76 percent), 4 (16 percent) were case-control studies, and 2 (8 percent) were cohort studies. Fifteen studies (60 percent) had a prospective design, 9 (36 percent) had a retrospective design, and one (4 percent) had both prospective and retrospective design. Thirty-two percent of the studies ( = 8) were performed in USA, and the remaining studies were performed in China ( = 4), Israel ( = 3), Netherlands ( = 3), UK ( = 1), France ( = 1), Italy ( = 1), Belgium( = 1), Germany ( = 1), Spain ( = 1), and Austria ( = 1). The prenatal diagnosis of micrognathia can be performed as early as possible in the first trimester, while the second and third trimester of pregnancy were the main prenatal diagnosis period. The articles that were included in the qualitative synthesis describe 30 biometric parameters related to the mandible.
Of the 30 biometric parameters related to the mandible, 15 can obtain the simple and convenient diagnostic criteria or warning value for micrognathia. Based on these diagnostic criteria or warning value, clinicians can quickly make a preliminary judgment on facial deformities, to carry out cytologic examination to further clarify the diagnosis of micrognathia.
本系统评价旨在分析不同小下颌诊断技术的特点，总结各技术一致的诊断标准，为小下颌提供简便的产前诊断策略。
按照系统评价和Meta分析的首选报告项目（PRISMA）指南，在三个国际数据库（PubMed、Scopus和Web of Science）中进行检索。三位评审员评估所有论文并提取以下变量：作者姓名和发表年份、国家、研究设计、参与者数量、孕周、产前检查设备、与小下颌相关的生物测量参数、主要结果。
分析共纳入25篇文章。19篇文章描述了横断面研究（76%），4篇（16%）为病例对照研究，2篇（8%）为队列研究。15项研究（60%）为前瞻性设计，9项（36%）为回顾性设计，1项（4%）兼具前瞻性和回顾性设计。32%的研究（n = 8）在美国进行，其余研究分别在中国（n = 4）、以色列（n = 3）、荷兰（n = 3）、英国（n = 1）、法国（n = 1）、意大利（n = 1）、比利时（n = 1）、德国（n = 1）、西班牙（n = 1）和奥地利（n = 1）进行。小下颌的产前诊断最早可在孕早期进行，而妊娠中晚期是主要的产前诊断时期。纳入定性综合分析的文章描述了30个与下颌骨相关的生物测量参数。
在30个与下颌骨相关的生物测量参数中，15个可得出小下颌的简便诊断标准或预警值。基于这些诊断标准或预警值，临床医生可对面部畸形迅速做出初步判断，进行细胞学检查以进一步明确小下颌的诊断。
