Jamieson Amanda M
Department of Microbiology and Immunology, Brown University, Providence, RI, USA.
Future Virol. 2016 Jul;11(7):529-534. doi: 10.2217/fvl-2016-0060. Epub 2016 Jul 1.
Recently, two coronaviruses, severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus, have emerged to cause unusually severe respiratory disease in humans. Currently, there is a lack of effective antiviral treatment options or vaccine available. Given the severity of these outbreaks, and the possibility of additional zoonotic coronaviruses emerging in the near future, the exploration of different treatment strategies is necessary. Disease resilience is the ability of a given host to tolerate an infection, and to return to a state of health. This review focuses on exploring various host resilience mechanisms that could be exploited for treatment of severe acute respiratory syndrome coronavirus, Middle East respiratory syndrome coronavirus and other respiratory viruses that cause acute lung injury and acute respiratory distress syndrome.
最近，两种冠状病毒，即严重急性呼吸综合征冠状病毒和中东呼吸综合征冠状病毒，出现并导致人类患上异常严重的呼吸道疾病。目前，缺乏有效的抗病毒治疗方案或可用疫苗。鉴于这些疫情的严重性，以及近期可能出现更多人畜共患冠状病毒的可能性，探索不同的治疗策略是必要的。疾病恢复力是指特定宿主耐受感染并恢复健康状态的能力。本综述着重探讨各种宿主恢复力机制，这些机制可用于治疗严重急性呼吸综合征冠状病毒、中东呼吸综合征冠状病毒以及其他导致急性肺损伤和急性呼吸窘迫综合征的呼吸道病毒。
