Martini Stefania, Arcadipane Francesca, Franco Pierfrancesco, Iorio Giuseppe C, Bartoncini Sara, Gallio Elena, Guarneri Alessia S, Ricardi Umberto
Department of Oncology, Radiation Oncology, University of Turin, Turin, Italy.
Department of Oncology, Radiation Oncology, A.O.U Citta' della Salute e della Scienza, Turin, Italy.
BJR Case Rep. 2020 Feb 12;6(1):20190021. doi: 10.1259/bjrcr.20190021. eCollection 2020 Mar.
At presentation, isolated metastasis from oropharyngeal squamous cell carcinoma is rare. Liver is a relatively uncommon first site of failure, especially in the absence of other distant metastases, particularly without diagnosis of lung metastases. We report on a case of HPV-related oropharyngeal squamous cell carcinoma with synchronous liver metastasis treated with radiation therapy. This condition, defined as "oligometastatic state," describes a subset of patients with limited volume metastatic disease in whom favorable outcomes were reported with the use of local ablative therapies on both the primary tumor and metastatic sites. As a definitive treatment, we offered the patient, ineligible for other therapeutic approaches, exclusive radiation treatment on the head and neck region and a stereotactic ablative approach targeted to the liver metastasis.
就诊时，口咽鳞状细胞癌的孤立性转移很少见。肝脏是相对不常见的首个失败部位，尤其是在没有其他远处转移的情况下，特别是未诊断出肺转移时。我们报告了1例接受放射治疗的HPV相关口咽鳞状细胞癌伴同步肝转移的病例。这种情况被定义为“寡转移状态”，描述了一组转移病灶体积有限的患者，据报道，对这些患者的原发肿瘤和转移部位采用局部消融治疗可取得良好疗效。作为确定性治疗，我们为不符合其他治疗方法条件的患者提供了针对头颈部区域的单纯放射治疗以及针对肝转移的立体定向消融治疗。
