Stott W T, Young J T, Calhoun L L, Battjes J E
Mammalian and Environmental Toxicology Research Laboratory, Dow Chemical Company, Midland, Michigan 48674.
Fundam Appl Toxicol. 1988 Aug;11(2):207-20. doi: 10.1016/0272-0590(88)90145-5.
In order to provide a comprehensive subchronic inhalation toxicity study of the soil fumigant, technical grade 1,3-dichloropropene (DCPT), male and female Fischer 344 rats and B6C3F1 mice were exposed to 0, 10, 30, 90, or 150 ppm DCPT vapors 6 hr/day, 5 days/week for 13 weeks. The primary target tissues of inhaled DCPT were identified as the nasal mucosa of both sexes of rats and mice, and the urinary bladder of female mice. In addition, depressed growth rates of all animals exposed to 90 or 150 ppm DCPT (up to 20% in rats and 12% in mice) resulted in a variety of alterations in hematologic and clinical chemistry parameters, and changes in organ weights relative to controls. Nasal mucosal effects consisted of a dose-related slight degenerative effect of nasal olfactory epithelium or a mild hyperplasia of the respiratory epithelium or both in all animals exposed to 90 or 150 ppm and 2 of 10 male rats exposed to 30 ppm DCPT. Some focal areas of respiratory metaplasia were also noted in high exposure group mice. Urinary bladder effects consisted of a diffuse, moderate hyperplasia of the transitional epithelium in female mice exposed to 90 or 150 ppm DCPT. No treatment-related effects were observed in rats or mice exposed to 10 ppm DCPT vapors.
为了对土壤熏蒸剂工业级1,3 - 二氯丙烯（DCPT）进行全面的亚慢性吸入毒性研究，将雄性和雌性Fischer 344大鼠以及B6C3F1小鼠，每天暴露于0、10、30、90或150 ppm的DCPT蒸气中6小时，每周5天，持续13周。吸入DCPT的主要靶组织被确定为大鼠和小鼠两性的鼻粘膜以及雌性小鼠的膀胱。此外，所有暴露于90或150 ppm DCPT的动物（大鼠高达20%，小鼠高达12%）生长速率降低，导致血液学和临床化学参数出现各种改变，以及器官重量相对于对照组发生变化。鼻粘膜效应包括在所有暴露于90或150 ppm的动物以及10只暴露于30 ppm DCPT的雄性大鼠中的2只中，鼻嗅觉上皮出现与剂量相关的轻微退行性效应或呼吸上皮轻度增生或两者皆有。在高暴露组小鼠中还观察到一些局灶性呼吸化生区域。膀胱效应包括暴露于90或150 ppm DCPT的雌性小鼠中移行上皮的弥漫性、中度增生。暴露于10 ppm DCPT蒸气的大鼠或小鼠未观察到与处理相关的效应。
