大鼠吸入暴露于1,3 - 二氯丙烯后巯基尿酸的排泄情况。

Mercapturic acid excretion by rats following inhalation exposure to 1,3-dichloropropene.

作者信息

Fisher G D, Kilgore W W

机构信息

Department of Environmental Toxicology, University of California, Davis 95616.

出版信息

Fundam Appl Toxicol. 1988 Aug;11(2):300-7. doi: 10.1016/0272-0590(88)90155-8.

DOI:10.1016/0272-0590(88)90155-8

PMID:3220208

Abstract

Rats were exposed to 1,3-dichloropropene (DCP), a commonly used agricultural nematicide, by inhalation to assess the relationship between DCP concentration and the urinary excretion of the mercapturic acid of cis-DCP (3C-NAC). The nose-only exposure system that was used for simultaneously exposing up to four rodents is described. This apparatus provided for generation and monitoring of relative humidity and test vapor concentration. Animals were exposed for 1 hr to concentrations of up to 789 ppm DCP. Urine was collected for 24 hr after exposure. The quantity of 3C-NAC contained in the urine collections exhibited an exposure concentration-dependent increase from 0 to 284 ppm DCP. However, the amount of 3C-NAC was no greater for animals exposed to 398 or 789 ppm DCP than for animals exposed to 284 ppm DCP.

摘要

将大鼠通过吸入方式暴露于常用的农业杀线虫剂1,3 - 二氯丙烯（DCP）中，以评估DCP浓度与顺式DCP（3C - NAC）的巯基尿酸尿排泄之间的关系。描述了用于同时暴露多达四只啮齿动物的仅经鼻暴露系统。该装置可用于产生和监测相对湿度以及测试蒸气浓度。动物暴露于浓度高达789 ppm的DCP中1小时。暴露后收集24小时尿液。尿液收集物中所含3C - NAC的量在DCP浓度从0至284 ppm时呈暴露浓度依赖性增加。然而，暴露于398或789 ppm DCP的动物的3C - NAC量并不比暴露于284 ppm DCP的动物更多。