顺式-1,3-二氯丙烯蒸气的皮肤吸收：人体实验性暴露

Dermal absorption of cis-1,3-dichloropropene vapour: human experimental exposure.

Kezić S, Monster A C, Verplanke A J, de Wolff F A

Coronel Laboratory, University of Amsterdam, The Netherlands.

Hum Exp Toxicol. 1996 May;15(5):396-9. doi: 10.1177/096032719601500506.

Abstract

The relevance of skin absorption of cis-1,3-dichloropropene (cis-1,3-DCP) vapour as a route of entry compared to inhalatory uptake has been assessed in human volunteers under controlled exposure conditions. 2. Five adults (four males and one female) were dermally exposed on the forearm and hand during 45 min to 86 mg/m3 cis-1,3-DCP. 3. Dermal uptake was assessed by determination of the main cis-1,3-DCP metabolite in urine: the mercapturic acid conjugate of cis-1,3-DCP (cis-1,3-DCP-MA). 4. When whole-body dermal exposure to vapour is compared to inhalatory exposure, the uptake through the skin is estimated to be about 2-5% of the inhalatory absorption.

摘要

在受控暴露条件下，已在人类志愿者中评估了顺式-1,3-二氯丙烯（顺式-1,3-DCP）蒸气经皮肤吸收作为一种进入途径与经吸入摄取相比的相关性。2. 五名成年人（四名男性和一名女性）在前臂和手部进行了45分钟的皮肤暴露，暴露于86毫克/立方米的顺式-1,3-DCP中。3. 通过测定尿液中主要的顺式-1,3-DCP代谢物：顺式-1,3-DCP的硫醚氨酸共轭物（顺式-1,3-DCP-MA）来评估皮肤摄取情况。4. 当将全身皮肤暴露于蒸气与吸入暴露进行比较时，经皮肤的摄取估计约为吸入吸收的2-5%。