Hanley T R, John-Greene J A, Young J T, Calhoun L L, Rao K S
Fundam Appl Toxicol. 1987 May;8(4):562-70. doi: 10.1016/0272-0590(87)90141-2.
1,3-Dichloropropene (DCP), which has found widespread use as a soil fumigant, was evaluated for its potential effects on embryonal and fetal development in rats and rabbits. Pregnant Fischer 344 rats and New Zealand White rabbits were exposed to 0, 20, 60, or 120 ppm of 1,3-dichloropropene for 6 hr/day during gestation Days 6-15 (rats) or 6-18 (rabbits). Exposure-related decreases in maternal weight gain and feed consumption were observed in rats at all treatment levels. Decreased weight gain was also observed among rabbits at 60 and 120 ppm. A slight, but statistically significant, increase in the incidence of delayed ossification of the vertebral centra in rats exposed in utero to 120 ppm of DCP was considered of little toxicologic significance in light of the maternal toxicity observed at this exposure concentration. No evidence of a teratogenic or embryotoxic response was observed in either species at any exposure level tested. Thus, it was concluded that DCP was not teratogenic at exposure levels up to 120 ppm in either rats or rabbits.
1,3 - 二氯丙烯（DCP）作为一种土壤熏蒸剂已被广泛使用，对其在大鼠和家兔胚胎及胎儿发育方面的潜在影响进行了评估。在妊娠第6至15天（大鼠）或第6至18天（家兔）期间，将怀孕的Fischer 344大鼠和新西兰白兔每天暴露于0、20、60或120 ppm的1,3 - 二氯丙烯中6小时。在所有处理水平下，大鼠均观察到与暴露相关的母体体重增加和饲料消耗减少。在60和120 ppm的家兔中也观察到体重增加减少。鉴于在该暴露浓度下观察到的母体毒性，子宫内暴露于120 ppm DCP的大鼠椎体中心骨化延迟发生率略有增加，但具有统计学意义，被认为毒理学意义不大。在任何测试的暴露水平下，两种物种均未观察到致畸或胚胎毒性反应。因此，得出结论，在大鼠或家兔中，暴露水平高达120 ppm时，DCP不具有致畸性。
