School of Health Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150, Malaysia.
School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, 16150, Malaysia.
Int J Neurosci. 2021 May;131(5):482-488. doi: 10.1080/00207454.2020.1746308. Epub 2020 Apr 2.
Hypoxia has been associated with cognitive impairment. Many studies have investigated the role of mTOR signalling pathway in cognitive functions but its role in hypoxia-induced cognitive impairment remains controversial. This review aimed to elucidate the role of mTOR in the mechanisms of cognitive impairment that may pave the way towards the mechanistic understanding and therapeutic intervention of hypoxia-induced cognitive impairment. mTORC1 is normally regulated during mild or acute hypoxic exposure giving rise to neuroprotection, whereas it is overactivated during severe or chronic hypoxia giving rise to neuronal cells death. Thus, it is worth exploring the possibility of maintaining normal mTORC1 activity and thereby preventing cognitive impairment during severe or chronic hypoxia.
缺氧与认知障碍有关。许多研究已经探讨了 mTOR 信号通路在认知功能中的作用，但它在缺氧诱导的认知障碍中的作用仍存在争议。本综述旨在阐明 mTOR 在认知障碍机制中的作用，这可能为缺氧诱导的认知障碍的机制理解和治疗干预铺平道路。mTORC1 在轻度或急性缺氧暴露期间通常受到调节，从而产生神经保护作用，而在严重或慢性缺氧期间过度激活，导致神经元细胞死亡。因此，探索在严重或慢性缺氧期间维持正常 mTORC1 活性并预防认知障碍的可能性是值得的。
