Abboud Miguel R
Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon.
Hematol Oncol Stem Cell Ther. 2020 Jun;13(2):85-90. doi: 10.1016/j.hemonc.2019.12.007. Epub 2020 Mar 12.
Sickle cell disease remains a major public health concern in sub-Saharan Africa, Europe, and the United States. The survival rate of children and adolescents has increased immensely in developed countries, whereas the survival rate for adults lagged behind. The increase in the pediatric survival rate is attributable to the institution of hydroxyurea treatment as well as stroke prevention strategies. In this review, we discuss the management of the sickle disease major complications such as pain, stroke, and acute chest syndrome with the most current hydroxyurea use and transfusion therapy.
镰状细胞病仍然是撒哈拉以南非洲、欧洲和美国主要的公共卫生问题。在发达国家，儿童和青少年的存活率大幅提高，而成年人的存活率则相对滞后。儿童存活率的提高归因于羟基脲治疗的应用以及中风预防策略。在这篇综述中，我们讨论镰状细胞病主要并发症（如疼痛、中风和急性胸综合征）的管理，以及最新的羟基脲使用情况和输血治疗。
