Nano Carbon Materials, Istituto Italiano di Tecnologia (IIT), via Livorno 60, 10144, Torino, Italy.
Department of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129, Torino, Italy.
Colloids Surf B Biointerfaces. 2020 Jun;190:110947. doi: 10.1016/j.colsurfb.2020.110947. Epub 2020 Mar 6.
Calcium carbonate nanoparticles (CaCONPs) derived from CO are promising materials for different industrial applications. It is imperative to understand their toxicological profile in biological systems as the human and environmental exposures to CaCONPs increases with growing production. Here, we analyse the cytotoxicity of CaCONPs synthesized from a CaO slurry on two cell lines, and in vivo on zebrafish (Danio Rerio). Our results demonstrate the CaCONPs in vitro safety as they do not cause cell death or genotoxicity. Moreover, zebrafish treated with CaCONPs develop without any abnormalities, confirming the safety and biocompatibility of this nanomaterial.
碳酸钙纳米粒子（CaCONPs）来源于 CO，是具有不同工业应用前景的材料。随着 CaCONPs 产量的增加，人类和环境对其的暴露也在增加，因此了解其在生物系统中的毒理学特征势在必行。在这里，我们分析了由 CaO 浆料合成的 CaCONPs 对两种细胞系以及斑马鱼（Danio Rerio）体内的细胞毒性。我们的结果表明，CaCONPs 在体外是安全的，因为它们不会导致细胞死亡或遗传毒性。此外，用 CaCONPs 处理的斑马鱼发育正常，没有任何异常，这证实了这种纳米材料的安全性和生物相容性。
