Luiz Marcela Tavares, di Filippo Leonardo Delello, Dutra Jessyca Aparecida Paes, Viegas Juliana Santos Rosa, Silvestre Amanda Letícia Polli, Anselmi Caroline, Duarte Jonatas Lobato, Calixto Giovana Maria Fioramonti, Chorilli Marlus
School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara 14800-903, São Paulo, Brazil.
Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal.
Pharmaceutics. 2023 Feb 24;15(3):762. doi: 10.3390/pharmaceutics15030762.
Dental caries is the most common oral disease, with high prevalence rates in adolescents and low-income and lower-middle-income countries. This disease originates from acid production by bacteria, leading to demineralization of the dental enamel and the formation of cavities. The treatment of caries remains a global challenge and the development of effective drug delivery systems is a potential strategy. In this context, different drug delivery systems have been investigated to remove oral biofilms and remineralize dental enamel. For a successful application of these systems, it is necessary that they remain adhered to the surfaces of the teeth to allow enough time for the removal of biofilms and enamel remineralization, thus, the use of mucoadhesive systems is highly encouraged. Among the systems used for this purpose, liquid crystalline systems, polymer-based nanoparticles, lipid-based nanoparticles, and inorganic nanoparticles have demonstrated great potential for preventing and treating dental caries through their own antimicrobial and remineralization properties or through delivering drugs. Therefore, the present review addresses the main drug delivery systems investigated in the treatment and prevention of dental caries.
龋齿是最常见的口腔疾病，在青少年以及低收入和中低收入国家中患病率很高。这种疾病源于细菌产生的酸，导致牙釉质脱矿并形成龋洞。龋齿的治疗仍然是一项全球性挑战，开发有效的药物递送系统是一种潜在策略。在这种背景下，人们研究了不同的药物递送系统来清除口腔生物膜并使牙釉质再矿化。为了这些系统的成功应用，有必要使其保持附着在牙齿表面，以便有足够的时间来清除生物膜和使牙釉质再矿化，因此，强烈鼓励使用粘膜粘附系统。在用于此目的的系统中，液晶系统、聚合物基纳米颗粒、脂质基纳米颗粒和无机纳米颗粒已通过其自身的抗菌和再矿化特性或通过递送药物，在预防和治疗龋齿方面显示出巨大潜力。因此，本综述阐述了在龋齿治疗和预防中所研究的主要药物递送系统。
