College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode, Kerala, India.
College of Pharmaceutical Sciences, Govt. Medical College, Kozhikode, Kerala, India.
Mater Sci Eng C Mater Biol Appl. 2020 May;110:110651. doi: 10.1016/j.msec.2020.110651. Epub 2020 Jan 8.
Carbon-based nanomaterials have established a prime position as drug delivery carriers. It is very interesting to see that a carbon nanostructure could be used as a drug too, instead of its regular application as a drug delivery carrier. In this aspect, graphene quantum dots (GQDs) are now in the spotlight. GQDs are one of the recent entrants to the list of carbon-based nanomaterials. They are now reported useful in Parkinson's and Alzheimer's diseases. Furthermore, antibacterial and anti-diabetic potentials of GQDs are now known. In addition, they are now widely evaluated for drug delivery application. They have good potential for drug delivery across the blood-brain barrier. Tumor-targeted drug delivery is also possible with GQDs. Their biosensing and bioimaging applications are also under extensive study. In this review, the therapeutic, drug delivery, biosensing and bioimaging applications of GQDs are described. It would be very interesting to speculate the future of GQDs and how this carbon nanomaterial influences the future of nanobiomedicine. It is presumed that drug-GQD duo would be the next generation strategy for many unresolved therapeutic hurdles.
碳基纳米材料在药物输送载体方面占据着首要地位。有趣的是,碳纳米结构也可以被用作药物,而不仅仅是作为药物输送载体的常规应用。在这方面,石墨烯量子点(GQDs)正成为焦点。GQDs 是碳基纳米材料中最新的一员。它们现在被报道在帕金森病和阿尔茨海默病中有用。此外,GQDs 还具有抗菌和抗糖尿病的潜力。此外,它们现在被广泛评估用于药物输送应用。它们具有很好的穿透血脑屏障的药物输送潜力。GQDs 也可用于肿瘤靶向药物输送。它们的生物传感和生物成像应用也在广泛研究中。在这篇综述中,描述了 GQDs 在治疗、药物输送、生物传感和生物成像方面的应用。推测 GQDs 的未来以及这种碳纳米材料如何影响纳米生物医学的未来将是非常有趣的。可以推测,药物-GQD 双管齐下将成为许多未解决的治疗障碍的下一代策略。