具有抗氧化潜力的可食用蘑菇中的脑苷脂和固醇。
Cerebrosides and Steroids from the Edible Mushroom with Antioxidant Potential.
机构信息
Department of Pharmacognosy, Interdisciplinary Excellence Centre, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary.
Spectroscopic Research Department, Gedeon Richter Plc., Gyömrői út 19-21, H-1103 Budapest, Hungary.
出版信息
Molecules. 2020 Mar 19;25(6):1395. doi: 10.3390/molecules25061395.
The detailed chemical analysis of the methanol extract of (Pers.) P. Karst. led to the isolation of two new cerebrosides, mericeramides A () and B () together with cerebroside B (), ergosterol (), 3β-hydroxyergosta-7,22-diene (), cerevisterol (), 3β-hydroxyergosta-6,8(14),22-triene (), 3β--glucopyranosyl-5,8-epidioxyergosta-6,22-diene () and (11,13)-9,10-dihydroxy-11,13-octadecadienoic acid (). The structures of the compounds were determined on the basis of NMR and MS spectroscopic analysis. Mericeramide A () is the first representative of halogenated natural cerebrosides. The isolated fungal metabolites - were evaluated for their antioxidant activity using the oxygen radical absorbance capacity (ORAC) assay. Compounds and proved to possess considerable antioxidant effects, with 2.50 ± 0.29, 4.94 ± 0.37 and 4.27 ± 0.05 mmol TE/g values, respectively. The result obtained gives a notable addition to the chemical and bioactivity profile of , highlighting the possible contribution of this species to a versatile and balanced diet.
（佩氏）曲霉菌甲醇提取物的详细化学成分分析导致了两种新的神经酰胺的分离，即 mericeramide A () 和 B () 以及神经酰胺 B ()、麦角甾醇 ()、3β-羟基麦角甾-7,22-二烯 ()、酵母甾醇 ()、3β-羟基麦角甾-6,8(14),22-三烯 ()、3β--葡萄糖吡喃基-5,8-表二氧麦角甾烷-6,22-二烯 () 和 (11,13)-9,10-二羟基-11,13-十八碳二烯酸 ()。这些化合物的结构是基于 NMR 和 MS 光谱分析确定的。Mericeramide A () 是首例含卤素的天然神经酰胺。评估了分离出的真菌代谢产物 - 的抗氧化活性，采用氧自由基吸收能力 (ORAC) 测定法。化合物 和 被证明具有相当大的抗氧化作用，其值分别为 2.50 ± 0.29、4.94 ± 0.37 和 4.27 ± 0.05 mmol TE/g。这一结果为 提供了化学和生物活性特征的显著补充，突出了该物种对多样化和均衡饮食的可能贡献。
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