Lu Qiang-Qiang, Tian Jun-Mian, Wei Jing, Gao Jin-Ming
a Department of Applied Chemistry, College of Science, Shaanxi Engineering Center of Bioresource Chemistry & Sustainable Utilization, Northwest A&F University , Yangling 712100 , Shaanxi , P.R. China.
Nat Prod Res. 2014;28(16):1288-92. doi: 10.1080/14786419.2014.898145. Epub 2014 Mar 18.
Seven known compounds, three diketopiperazine alkaloids, 12β-hydroxyverruculogen TR-2 (1), fumitremorgin C (2) and methylthiogliotoxin (5), two hetero-spirocyclic γ-lactam alkaloids, pseurotin A (3) and FD-838 (4), and cerevisterol (6) and herierin IV (7), were isolated from the mycelia of the basidiomycete Hericium erinaceum and identified by spectroscopic analyses. The antioxidant and antifungal activities of compounds 1-6 were evaluated. The results indicated that compounds 1, 3 and 6 exhibited potential antioxidant activity against DPPH (2, 2-diphenyl-1-picrylhydrazyl) radical with their IC50 data of ca. 12 μM, compared with positive control tertiary butylhydroquinone. In addition, compound 4 significantly inhibited the growth of two plant fungal pathogens Botrytis cinerea and Glomerella cingulata with an minimum inhibitory concentration of 6.25 μM for each, similar to that of the positive fungicide, carbendazim. Compounds 1-5 were isolated from the genus Hericium for the first time.
从担子菌猴头菌的菌丝体中分离出7种已知化合物，3种二酮哌嗪生物碱，12β-羟基疣孢菌素TR-2（1）、烟曲霉震颤素C（2）和甲基硫代胶毒素（5），2种杂螺环γ-内酰胺生物碱，假密环菌素A（3）和FD-838（4），以及麦角甾醇（6）和猴头菌素IV（7），并通过光谱分析进行了鉴定。对化合物1-6的抗氧化和抗真菌活性进行了评估。结果表明，与阳性对照叔丁基对苯二酚相比，化合物1、3和6对2,2-二苯基-1-苦基肼自由基（DPPH）表现出潜在的抗氧化活性，其半数抑制浓度（IC50）约为12 μM。此外，化合物4对两种植物真菌病原体灰葡萄孢菌和炭疽菌有显著的抑制作用，其最低抑菌浓度均为6.25 μM，与阳性杀菌剂多菌灵相似。化合物1-5首次从猴头菌属中分离得到。
