纤维钙化性（热带）胰腺糖尿病中的胰岛素抵抗

Insulin resistance in Fibrocalculous (tropical) pancreatic diabetes.

作者信息

Mohan V, Ramachandran A, Vijay Kumar G, Snehalatha C, Viswanathan M

机构信息

Diabetes Research Centre, Madras, India.

出版信息

Horm Metab Res. 1988 Dec;20(12):746-8. doi: 10.1055/s-2007-1010937.

DOI:10.1055/s-2007-1010937

PMID:3220451

Abstract

Insulin resistance was assessed by Insulin Tolerance Test (ITT) in 12 patients with FCPD, 10 with NIDDM and 12 age and sex matched control subjects. The mean BMI of the FCPD was lower than the NIDDM and control groups (P less than 0.001). There was no significant difference between the mean fasting plasma glucose or HbA1 between the FCPD and NIDDM patients. The mean fasting C-peptide of the FCPD group was significantly lower than the NIDDM and control groups (P less than 0.001). The mean glucose disposal rate (KITT) was 5.57 +/- 2.28 in the control group, 2.15 +/- 2.00 in the FCPD and 1.77 +/- 0.91 in the NiDDM group (P less than 0.001, control vs FCPD and NIDDM). The difference in KITT between FCPD and NIDDM groups was not significant statistically. The data suggests that patients with FCPD have evidence of insulin resistance and this is similar to that seen in NIDDM patients.

摘要

通过胰岛素耐量试验（ITT）对12例慢性胰腺炎伴糖尿病（FCPD）患者、10例非胰岛素依赖型糖尿病（NIDDM）患者以及12例年龄和性别匹配的对照者进行胰岛素抵抗评估。FCPD患者的平均体重指数低于NIDDM患者组和对照组（P<0.001）。FCPD患者与NIDDM患者的空腹血糖均值或糖化血红蛋白（HbA1）之间无显著差异。FCPD组的空腹C肽均值显著低于NIDDM组和对照组（P<0.001）。对照组的平均葡萄糖处置率（KITT）为5.57±2.28，FCPD组为2.15±2.00，NIDDM组为1.77±0.91（对照组与FCPD组及NIDDM组相比，P<0.001）。FCPD组与NIDDM组之间的KITT差异无统计学意义。数据表明，FCPD患者存在胰岛素抵抗证据，且与NIDDM患者所见相似。