Barreca T, Franceschini R, Siani C, Messina V, Francaviglia N, Perria C, Rolandi E
Department of Internal Medicine, University of Genoa, Italy.
Horm Res. 1988;30(1):28-31. doi: 10.1159/000181022.
The arginine vasopressin (AVP) concentrations were determined in plasma and in cerebrospinal fluid (CSF) during a 24-hour period in 7 male patients suffering from hydrocephalus of differing etiologies. Blood and ventricular CSF samples were simultaneously collected every 2 h during the day (08.00-22.00) and every hour during the night (24.00-07.00). In both plasma and CSF, the AVP levels did not show significant time-related circadian variations. No significant correlation was found between the plasma and CSF AVP values during the 24-hour period. The data obtained indicate the absence of the plasma and CSF AVP circadian rhythm in hydrocephalic patients and suggest that in these patients, and possibly in healthy humans, physiological stimuli which are able to induce variations in the plasma AVP concentration during daily life do not alter the CSF AVP content.
在7名病因各异的脑积水男性患者中，测定了他们24小时内血浆和脑脊液（CSF）中的精氨酸加压素（AVP）浓度。白天（08:00 - 22:00）每2小时同时采集一次血液和脑室CSF样本，夜间（24:00 - 07:00）每小时采集一次。血浆和CSF中的AVP水平均未显示出与时间相关的昼夜节律变化。在24小时期间，血浆和CSF的AVP值之间未发现显著相关性。所获得的数据表明脑积水患者血浆和CSF中不存在AVP昼夜节律，并提示在这些患者以及可能在健康人中，日常生活中能够诱导血浆AVP浓度变化的生理刺激不会改变CSF中AVP的含量。
