Sørensen P S, Hammer M, Gjerris F, Lundberg J
Regul Pept. 1985 Mar;10(2-3):115-26. doi: 10.1016/0167-0115(85)90006-0.
The variation in vasopressin concentrations of ventricular cerebrospinal fluid and plasma throughout a 24-h period was studied in 10 patients with hydrocephalus. In 6 control patients, the diurnal variation in plasma vasopressin concentrations was studied. Vasopressin concentrations were determined by radioimmunoassay in plasma and in extracted and unextracted cerebrospinal fluid. Cortisol and osmolality in plasma were also measured. Vasopressin concentrations measured in extracted cerebrospinal fluid showed only small intra- and interindividual variation, while the corresponding values for unextracted cerebrospinal fluid were 2-5-fold higher and showed more variation. Plasma vasopressin concentrations varied considerably throughout the 24-h period in the individual hydrocephalic patient and between the patients. The pattern of variation was inconstant with no circadian rhythm, and the variation was not related to any changes in plasma osmolality, blood pressure or intracranial pressure. In some of the patients, the normal diurnal pattern of variation in plasma cortisol was broken, however, without a relation to the observed fluctuations in vasopressin concentrations. The abnormal variation of plasma vasopressin and cortisol was considered to reflect stress in connection with the intracranial pressure monitoring procedure. In the control patients, plasma vasopressin showed only small variations and plasma cortisol showed a normal diurnal rhythm. It is concluded that cerebrospinal fluid vasopressin concentration in patients with hydrocephalus is very constant throughout the day, even when plasma vasopressin concentrations show marked episodic increases. Thus, a circadian rhythm in the cerebrospinal fluid vasopressin concentration, as reported in several animal species, could not be confirmed in these patients.
对10例脑积水患者24小时内脑室脑脊液和血浆中血管加压素浓度的变化进行了研究。对6例对照患者的血浆血管加压素浓度的昼夜变化进行了研究。采用放射免疫分析法测定血浆、提取和未提取脑脊液中的血管加压素浓度。还测量了血浆中的皮质醇和渗透压。提取脑脊液中测得的血管加压素浓度个体内和个体间差异较小，而未提取脑脊液的相应值则高2 - 5倍且差异更大。个体脑积水患者以及患者之间，血浆血管加压素浓度在24小时内变化很大。变化模式不稳定，无昼夜节律，且这种变化与血浆渗透压、血压或颅内压的任何变化均无关。在一些患者中，血浆皮质醇正常的昼夜变化模式被打破，然而，这与观察到的血管加压素浓度波动无关。血浆血管加压素和皮质醇的异常变化被认为反映了与颅内压监测过程相关的应激反应。在对照患者中，血浆血管加压素仅显示出微小变化，血浆皮质醇显示出正常的昼夜节律。得出的结论是，脑积水患者脑脊液中的血管加压素浓度在一天中非常恒定，即使血浆血管加压素浓度出现明显的间歇性升高。因此，在这些患者中无法证实几种动物物种中报道的脑脊液血管加压素浓度的昼夜节律。
