Barreca T, Siani C, Franceschini R, Francaviglia N, Messina V, Perria C, Rolandi E
Life Sci. 1986 Jun 16;38(24):2263-7. doi: 10.1016/0024-3205(86)90579-5.
Plasma and cerebrospinal fluid (CSF) beta-endorphin levels were determined by a RIA method in seven hydrocephalic male patients. The samples were simultaneously collected every two hours from 8 AM to 12 midnight and every hour from 1 AM to 7 AM. In both plasma and CSF beta-endorphin levels showed significant time-related variations during the 24 hour period. These results suggest the existence of diurnal CSF beta-endorphin variations analogous to those observed in plasma.
