Department of Otolaryngology-Head and Neck Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Department of Radiation Oncology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania, USA.
Otolaryngol Head Neck Surg. 2020 Aug;163(2):372-374. doi: 10.1177/0194599820913604. Epub 2020 Mar 24.
Human papillomavirus (HPV)-positive oropharynx squamous cell carcinoma (OPSCC) is known to have improved survival over HPV-negative disease. However, it is largely unknown whether HPV status similarly affects survival in patients presenting with distant metastatic disease. We queried the National Cancer Database for OPSCC with distant metastasis. Kaplan-Meier curves and Cox proportional hazards regression models controlling for relevant demographics were used to evaluate overall survival. In total, 768 OPSCC cases were available for analysis with HPV and survival data: 50% of cases were HPV negative and 50% were HPV positive. The 1- and 2-year survival for HPV-negative disease was 49% and 27%, respectively, as compared with 67% and 42% in the HPV-positive cohort. HPV positivity was associated with improved median survival in treated and untreated patients. Age, comorbidities, and HPV status were predictive of improved survival on multivariate analysis. HPV-positive OPSCC has improved survival in the setting of distant metastatic presentation as compared with HPV-negative disease and shows greater responsiveness to treatment.
人乳头瘤病毒（HPV）阳性口咽鳞状细胞癌（OPSCC）的生存率高于 HPV 阴性疾病已为人所知。然而，HPV 状态是否同样影响远处转移疾病患者的生存率在很大程度上尚不清楚。我们在国家癌症数据库中查询了伴有远处转移的 OPSCC。使用 Kaplan-Meier 曲线和 Cox 比例风险回归模型控制相关人口统计学因素来评估总生存率。共有 768 例 OPSCC 病例可用于分析 HPV 和生存数据：50%的病例 HPV 阴性，50%的病例 HPV 阳性。HPV 阴性疾病的 1 年和 2 年生存率分别为 49%和 27%，而 HPV 阳性组则分别为 67%和 42%。HPV 阳性与治疗和未治疗患者的中位生存期延长相关。多变量分析显示，年龄、合并症和 HPV 状态与生存改善相关。与 HPV 阴性疾病相比，HPV 阳性 OPSCC 在远处转移表现时的生存率有所提高，并且对治疗的反应性更强。
