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童年贫困对大脑健康的影响:神经影像学在整个生命周期中的新证据。

The impact of childhood poverty on brain health: Emerging evidence from neuroimaging across the lifespan.

机构信息

Department of Psychology, University of Denver, Denver, CO, United States.

Department of Psychology, University of Denver, Denver, CO, United States.

出版信息

Int Rev Neurobiol. 2020;150:77-105. doi: 10.1016/bs.irn.2019.12.001. Epub 2019 Dec 18.

Abstract

Experiencing poverty in childhood has been associated with increased risk for physical and mental health difficulties later in life. An emerging body of evidence suggests that brain development may be one mediator of this relation. In this chapter, we discuss evidence for an association between childhood poverty and brain structure/function. First, we examine the association from a lifespan perspective discussing studies at multiple developmental stages from the prenatal period to late adulthood. Second, we examine existing studies that link childhood poverty, brain development, and physical and mental health outcomes. Third, we discuss studies linking childhood poverty and environmental risks and protective factors. Lastly, we discuss suggestions for future studies including advances in network neuroscience, population neuroscience, using multiple imaging modalities, and the use of longitudinal neuroimaging studies. Overall, associations between childhood poverty, brain development, and development over the life course may help to both better understand and eventually reveal salient intervention strategies to mitigate social disparities in health.

摘要

童年时期经历贫困与日后身心健康问题风险增加有关。越来越多的证据表明,大脑发育可能是这种关系的一个中介因素。在本章中,我们讨论了童年贫困与大脑结构/功能之间的关联的证据。首先,我们从生命全程的角度探讨了这一关联,讨论了从产前到成年后期的多个发育阶段的研究。其次,我们考察了将童年贫困、大脑发育与身心健康结果联系起来的现有研究。第三,我们讨论了将童年贫困与环境风险和保护因素联系起来的研究。最后,我们讨论了未来研究的建议,包括网络神经科学、人群神经科学的进展,使用多种成像方式,以及进行纵向神经影像学研究。总体而言,童年贫困、大脑发育和整个生命过程中的发展之间的关联,可能有助于更好地理解,并最终揭示缓解健康方面社会差异的显著干预策略。

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