RAND Corporation, Santa Monica, CA, USA.
RAND Corporation, Santa Monica, CA, USA; University of Washington, Seattle, WA, USA.
J Hosp Infect. 2020 Jun;105(2):225-231. doi: 10.1016/j.jhin.2020.03.019. Epub 2020 Mar 20.
A clinically noticeable increase in Clostridioides difficile infections (CDI) in excess of expectations (i.e. outbreak) lacks a common definition. Understanding what magnitude of CDI incidence growth constitutes an outbreak from the hospital perspective is valuable for retrospective analyses. This study identified CDI incidence metrics reported as outbreaks in the literature and compared these with Healthcare Cost and Utilization Project (HCUP) discharge data. Publications reported a median 4.1x incidence change between outbreak periods and reference periods (N=26, minimum 2x incidence). However, this magnitude change in monthly incidence appeared once in HCUP data (20 hospitals, 2012-2014). Hence, the literature may present examples of extreme outbreaks.
临床上显著超过预期的艰难梭菌感染（CDI）增加（即暴发）缺乏一个通用的定义。从医院的角度理解多大程度的 CDI 发病率增长构成暴发对于回顾性分析是有价值的。本研究确定了文献中报告的 CDI 发病率指标作为暴发，并将这些与医疗保健成本和利用项目（HCUP）的出院数据进行了比较。出版物报告暴发期和参照期之间发病率中位数变化 4.1 倍（N=26，最低 2 倍发病率）。然而，HCUP 数据中每月发病率仅出现过一次这种幅度的变化（20 家医院，2012-2014 年）。因此，文献中可能呈现了极端暴发的例子。
