Department of Anesthesiology, Critical Care and Pain Medicine, Cardiac Anesthesia Division, Boston Children's Hospital, Boston, Massachusetts, USA
Department of Anaesthesia, Harvard Medical School, Boston, Massachusetts, USA.
Infect Immun. 2020 May 20;88(6). doi: 10.1128/IAI.00031-20.
Sepsis remains medically challenging, with high morbidity and mortality. A novel intervention is urgently needed in the absence of specific, targeted therapy. Neutrophils act as double-edged swords in sepsis; they can help to eradicate microbes, but they also contribute to tissue injury. β2 integrins are critical adhesion molecules that regulate a number of neutrophil functions. β2 integrins consist of four members, namely, αLβ2, αMβ2, αXβ2, and αDβ2. Here, we review the role of each β2 integrin in neutrophils and sepsis and consider future direction for therapeutic intervention.
脓毒症仍然是医学上的挑战，具有高发病率和死亡率。在缺乏特异性靶向治疗的情况下，迫切需要新的干预措施。中性粒细胞在脓毒症中是一把双刃剑；它们可以帮助消灭微生物，但也会导致组织损伤。β2 整合素是调节多种中性粒细胞功能的关键黏附分子。β2 整合素由四个成员组成，即 αLβ2、αMβ2、αXβ2 和 αDβ2。在这里，我们回顾了每个β2 整合素在中性粒细胞和脓毒症中的作用，并考虑了治疗干预的未来方向。
