Department of Gastroenterology and Hepatology, People's Hospital of Zhengzhou University, Henan Provincial People's Hospital, and Henan University School of Medicine, Zhengzhou 450003, Henan Province, China.
World J Gastroenterol. 2020 Mar 14;26(10):995-1004. doi: 10.3748/wjg.v26.i10.995.
() infects approximately 50% of the world population. The multiple gastrointestinal and extra-gastrointestinal diseases caused by infection pose a major healthcare threat to families and societies; it is also a heavy economic and healthcare burden for countries that having high infection rates. Eradication of is recommended for all infected individuals. Traditionally, "test and treat" and "screen and treat" strategies are available for various infected populations. However, clinical practice has noticed that these strategies have some shortfalls and may need refinement, mostly due to the fact that they are not easily manageable, and are affected by patient compliance, selection of treatment population and cost-benefit estimations. Furthermore, it is difficult to control infections from the source, therefore, development of additional, compensative strategies are encouraged to solve the above problems and facilitate bacteria eradication. infection is a family-based disease, but few studies have been performed in a whole family-based approach to curb its intra-familial transmission and the development of related diseases. In this work, a third, novel whole family-based eradication strategy is introduced. This approach screens, identifies, treats and follows up on all -infected individuals in entire families to control infection among family members, and reduce its long-term complications. This strategy is high-risk population-oriented, and able to reduce spread among family members. It also has good patient-family compliance and, importantly, is practical for both high and low -infected communities. Future efforts in these areas will be critical to initiate and establish healthcare policies and management strategies to reduce -induced disease burden for society.
感染了世界上大约 50%的人口。感染引起的多种胃肠道和胃肠道外疾病对家庭和社会构成了重大的医疗保健威胁；对于感染率高的国家来说，它也是一个沉重的经济和医疗保健负担。建议对所有感染个体进行根除。传统上，有“检测和治疗”和“筛查和治疗”策略可用于各种感染人群。然而，临床实践注意到这些策略存在一些缺陷，可能需要改进，主要是因为它们不容易管理，并且受到患者依从性、治疗人群选择和成本效益评估的影响。此外，从源头控制感染很困难，因此，鼓励开发额外的补偿性策略来解决上述问题并促进细菌根除。感染是一种基于家庭的疾病，但很少有研究采用全家庭方法来遏制其家庭内传播和相关疾病的发展。在这项工作中，引入了第三种新的全家庭根除策略。该方法对所有感染个体进行筛查、识别、治疗和随访，以控制家庭成员中的感染，并减少其长期并发症。该策略以高危人群为导向，能够减少家庭成员之间的传播。它还具有良好的患者-家庭依从性，重要的是，对于高感染和低感染社区都实用。在这些领域的未来努力对于启动和建立医疗保健政策和管理策略以减轻社会因感染引起的疾病负担至关重要。
