用于肺动脉高压患者静脉输注曲前列尼尔的完全植入式泵的流速变化
Flow rate variance of a fully implantable pump for the delivery of intravenous treprostinil in pulmonary arterial hypertension.
作者信息
Richter Manuel J, Harutyunova Satenik, Bollmann Tom, Classen Simon, Fuge Jan, Gall Henning, Gerhardt Felix, Ghofrani Hossein A, Gunkel Hartmut, Grünig Ekkehard, Halank Michael, Heine Alexander, Klose Hans, Lange Tobias J, Neurohr Claus, Nickolaus Kai, Opitz Christian F, Rosenkranz Stephan, Seyfarth Hans-Jürgen, Tello Khodr, Ewert Ralf, Olsson Karen M
机构信息
Department of Pneumology, Kerckhoff Heart, Rheuma and Thoracic Center, Bad Nauheim, Germany.
Department of Internal Medicine, Justus Liebig University Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), Giessen, Germany.
出版信息
Pulm Circ. 2020 Mar 13;10(1):2045894020910136. doi: 10.1177/2045894020910136. eCollection 2020 Jan-Mar.
Implantable infusion pumps might improve the convenience and safety of intravenous treprostinil for pulmonary arterial hypertension. The LENUS Pro® pump (approved in Europe) has a fixed flow rate. Based on 126 pumps and 2853 refills, we retrospectively analyzed the actual flow rate from 09/2010 to 09/2018. A relevant flow rate variance is evident after three years; therefore, flow rate monitoring and dose adjustment are mandatory.
植入式输液泵可能会提高静脉注射曲前列尼尔治疗肺动脉高压的便利性和安全性。LENUS Pro®泵（在欧洲获批）具有固定流速。基于126台泵和2853次补充装液，我们回顾性分析了2010年9月至2018年9月期间的实际流速。三年后明显出现了相关的流速差异；因此，流速监测和剂量调整是必不可少的。
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