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肺动脉高压患者使用植入式输注泵静脉输注曲前列尼尔的长期经验——操作安全性及与系统相关的并发症

Long-term experience with implantable infusion pumps for intravenous treprostinil in pulmonary arterial hypertension-procedural safety and system-related complications.

作者信息

Steringer-Mascherbauer Regina, Lummersdorfer Maria, Függer Reinhold, Sigmund Elisabeth, Huber Charlotte, Engleder Dagmar, Fröschl Uwe, Aichinger Josef

机构信息

Department of Cardiology, Ordensklinikum Linz GmbH Elisabethinen, Linz, Austria.

Institute for Anesthesiology and Intensive Care, Ordensklinikum Linz GmbH Elisabethinen, Linz, Austria.

出版信息

Pulm Circ. 2020 Nov 30;10(4):2045894020970830. doi: 10.1177/2045894020970830. eCollection 2020 Oct-Dec.

DOI:10.1177/2045894020970830
PMID:33299542
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7711148/
Abstract

Implantable pumps for intravenous treprostinil provide a promising option to overcome drawbacks of parenteral prostanoid administration with external pumps in pulmonary hypertension. We retrospectively analyzed 85 patients undergoing implantation in a single center since 2010. In our cohort, serious complications were rare, and flow rate increase over time warrants careful monitoring.

摘要

用于静脉注射曲前列尼尔的植入式泵为克服肺动脉高压患者使用外置泵进行胃肠外前列腺素给药的缺点提供了一个有前景的选择。我们回顾性分析了自2010年以来在单一中心接受植入手术的85例患者。在我们的队列中，严重并发症很少见，且随着时间推移流速增加需要仔细监测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c41e/7711148/beb58c03eb5f/10.1177_2045894020970830-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c41e/7711148/beb58c03eb5f/10.1177_2045894020970830-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c41e/7711148/beb58c03eb5f/10.1177_2045894020970830-fig1.jpg

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本文引用的文献

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Pulm Circ. 2020 Mar 13;10(1):2045894020910136. doi: 10.1177/2045894020910136. eCollection 2020 Jan-Mar.
2
Long-term safety and outcome of intravenous treprostinil via an implanted pump in pulmonary hypertension.肺动脉高压患者经植入式输液港输注曲前列尼尔的长期安全性和结局。
J Heart Lung Transplant. 2018 Oct;37(10):1235-1244. doi: 10.1016/j.healun.2018.06.006. Epub 2018 Jun 21.
3
Intravenous treprostinil via an implantable pump in pediatric pulmonary arterial hypertension.
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Pulm Circ. 2019 Jan-Mar;9(1):2045894018788846. doi: 10.1177/2045894018788846. Epub 2018 Jun 26.
4
An implantable pump Lenus pro® in the treatment of pulmonary arterial hypertension with intravenous treprostinil.植入式 Lenus pro® 泵联合静脉注射曲前列尼尔治疗肺动脉高压。
BMC Pulm Med. 2017 Dec 2;17(1):162. doi: 10.1186/s12890-017-0474-7.
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2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT).2015 ESC/ERS 肺动脉高压诊断与治疗指南：欧洲心脏病学会（ESC）和欧洲呼吸学会（ERS）肺动脉高压诊断与治疗工作组制定：该指南得到了欧洲儿科和先天性心脏病协会（AEPC）以及国际心肺移植学会（ISHLT）的认可。
Eur Respir J. 2015 Oct;46(4):903-75. doi: 10.1183/13993003.01032-2015. Epub 2015 Aug 29.
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Long-term treatment, tolerability, and survival with sub-cutaneous treprostinil for severe pulmonary hypertension.长期皮下注射曲前列尼尔治疗重度肺动脉高压的疗效、耐受性和生存率。
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Pulmonary hypertension: an important predictor of outcomes in patients undergoing non-cardiac surgery.肺动脉高压：非心脏手术患者预后的重要预测指标。
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