• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

合成与生物相容性羧甲基化壳聚糖修饰的超顺磁性FeO结合的有效染料木黄酮以对抗急性白血病淋巴瘤。

Synthesizing efficacious genistein in conjugation with superparamagnetic FeO decorated with bio-compatible carboxymethylated chitosan against acute leukemia lymphoma.

作者信息

Ghasemi Goorbandi Rachel, Mohammadi Mohammad Reza, Malekzadeh Kianoosh

机构信息

1Sharif University of Technology, Kish International Campus, Kish Island, Iran.

2Molecular Medicine Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

出版信息

Biomater Res. 2020 Mar 20;24:9. doi: 10.1186/s40824-020-00187-2. eCollection 2020.

DOI:10.1186/s40824-020-00187-2
PMID:32206338
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7082912/
Abstract

BACKGROUND

Genistein (CHO) is a soy isoflavone with anti-cancer properties such as inhibition of cell growth, proliferation and tumor invasion, but effective dosage against hematopoietic malignant cells was not in non-toxic range. This property cause to impede its usage as chemotherapeutic agent. Therefore, this hypothesis raised that synthesizing biocompatible nanoparticle could assist to prevail this struggle.

METHODS

Genistein covalently attached on FeO nanoparticles decorated with carboxymethylated chitosan to fabricate FeO-CMC-genistein in alkaline circumstance. This obtained nanoparticles were evaluated by TEM, DLS, FTIR, XRD and VSM and its anti-cancer effect by growth rate and MTT assays as well as flow cytometer on ALL cancer cell lines.

RESULTS

Different evaluations indicated that the drug delivery vehicle had a mean diameter size around 12ƞm with well bounded components. This system presented high degree of magnetization and superparamagnetic properties as well as good water solubility. In comparison with pure genistein, significant growth inhibition on hematopoietic cancer cells in lower dose of genistein nano-conjugated onto FeO-CMC. It increased long lasting effect of genistein in cancer cells also.

CONCLUSION

This delivery system for genistein could be remarkably promised and futuristic as biocompatible chemotherapeutic agent against hematopoietic malignant cells.

摘要

背景

染料木黄酮（CHO）是一种具有抗癌特性的大豆异黄酮，如抑制细胞生长、增殖和肿瘤侵袭，但对造血恶性细胞有效的剂量不在无毒范围内。这一特性阻碍了其作为化疗药物的使用。因此，有人提出合成生物相容性纳米颗粒可能有助于克服这一难题。

方法

在碱性环境下，将染料木黄酮共价连接到用羧甲基化壳聚糖修饰的FeO纳米颗粒上，制备FeO-CMC-染料木黄酮。通过透射电子显微镜（TEM）、动态光散射（DLS）、傅里叶变换红外光谱（FTIR）、X射线衍射（XRD）和振动样品磁强计（VSM）对所得纳米颗粒进行评估，并通过生长速率、MTT试验以及流式细胞仪对所有癌细胞系评估其抗癌效果。

结果

不同的评估表明，该药物递送载体的平均直径约为12μm，各成分结合良好。该系统具有高度的磁化强度和超顺磁性，以及良好的水溶性。与纯染料木黄酮相比，较低剂量的染料木黄酮纳米共轭物FeO-CMC对造血癌细胞具有显著的生长抑制作用。它还增强了染料木黄酮在癌细胞中的持久作用。

结论

这种染料木黄酮递送系统有望成为一种针对造血恶性细胞的生物相容性化疗药物，具有显著前景和未来应用价值。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba0c/7082912/b4ad788177af/40824_2020_187_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba0c/7082912/7b550ac9c273/40824_2020_187_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba0c/7082912/9b5966a3b1c9/40824_2020_187_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba0c/7082912/bcd9eefc9ccc/40824_2020_187_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba0c/7082912/6d91a84a7575/40824_2020_187_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba0c/7082912/6fd243b12d38/40824_2020_187_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba0c/7082912/641bea049ac4/40824_2020_187_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba0c/7082912/3905151ac18a/40824_2020_187_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba0c/7082912/2c255db0e674/40824_2020_187_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba0c/7082912/a6a6e9d27edb/40824_2020_187_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba0c/7082912/b4ad788177af/40824_2020_187_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba0c/7082912/7b550ac9c273/40824_2020_187_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba0c/7082912/9b5966a3b1c9/40824_2020_187_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba0c/7082912/bcd9eefc9ccc/40824_2020_187_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba0c/7082912/6d91a84a7575/40824_2020_187_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba0c/7082912/6fd243b12d38/40824_2020_187_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba0c/7082912/641bea049ac4/40824_2020_187_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba0c/7082912/3905151ac18a/40824_2020_187_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba0c/7082912/2c255db0e674/40824_2020_187_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba0c/7082912/a6a6e9d27edb/40824_2020_187_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba0c/7082912/b4ad788177af/40824_2020_187_Fig10_HTML.jpg

相似文献

1
Synthesizing efficacious genistein in conjugation with superparamagnetic FeO decorated with bio-compatible carboxymethylated chitosan against acute leukemia lymphoma.合成与生物相容性羧甲基化壳聚糖修饰的超顺磁性FeO结合的有效染料木黄酮以对抗急性白血病淋巴瘤。
Biomater Res. 2020 Mar 20;24:9. doi: 10.1186/s40824-020-00187-2. eCollection 2020.
2
Improving the anti-tumor effect of genistein with a biocompatible superparamagnetic drug delivery system.利用生物相容性超顺磁性药物递送系统提高染料木黄酮的抗肿瘤效果。
J Nanosci Nanotechnol. 2010 Apr;10(4):2325-31. doi: 10.1166/jnn.2010.1913.
3
Bioconjugation of papain on superparamagnetic nanoparticles decorated with carboxymethylated chitosan.木瓜蛋白酶在羧甲基化壳聚糖修饰的超顺磁性纳米颗粒上的生物共轭。
Biomacromolecules. 2007 May;8(5):1480-6. doi: 10.1021/bm061091g. Epub 2007 Mar 27.
4
The Effects of Nanoencapsulated Curcumin-Fe3O4 on Proliferation and hTERT Gene Expression in Lung Cancer Cells.纳米包封姜黄素 - Fe3O4对肺癌细胞增殖及hTERT基因表达的影响
Anticancer Agents Med Chem. 2017;17(10):1363-1373. doi: 10.2174/1871520617666170213115756.
5
Magnetic bio-metal-organic framework nanocomposites decorated with folic acid conjugated chitosan as a promising biocompatible targeted theranostic system for cancer treatment.基于叶酸修饰壳聚糖的磁性生物金属有机框架纳米复合材料作为一种有前途的生物兼容靶向治疗癌症的诊断与治疗一体化系统。
Mater Sci Eng C Mater Biol Appl. 2019 Jun;99:805-815. doi: 10.1016/j.msec.2019.02.017. Epub 2019 Feb 6.
6
[Preparation of superparamagnetic paclitaxel nanoparticles from modified chitosan and their cytotoxicity against malignant brain glioma].[基于改性壳聚糖的超顺磁性紫杉醇纳米粒的制备及其对恶性脑胶质瘤的细胞毒性]
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2011 Jun;28(3):513-6.
7
Stimuli-responsive hybrid cluster bombs of PEGylated chitosan encapsulated DOX-loaded superparamagnetic nanoparticles enabling tumor-specific disassembly for on-demand drug delivery and enhanced MR imaging.载阿霉素的超顺磁纳米粒子聚乙二醇化壳聚糖复合囊泡型刺激响应型炸弹，可实现肿瘤特异性按需药物释放和增强磁共振成像的可控组装与解组装。
Carbohydr Polym. 2019 Feb 1;205:377-384. doi: 10.1016/j.carbpol.2018.10.076. Epub 2018 Oct 28.
8
In situ decorated Au NPs on chitosan-encapsulated FeO-NH NPs as magnetic nanocomposite: Investigation of its anti-colon carcinoma, anti-gastric cancer and anti-pancreatic cancer.壳聚糖包被的 FeO-NH 纳米粒子原位修饰金纳米粒子的磁性纳米复合材料：对其抗结肠癌、胃癌和胰腺癌的研究。
Int J Biol Macromol. 2021 Feb 28;171:198-207. doi: 10.1016/j.ijbiomac.2020.12.037. Epub 2020 Dec 10.
9
Fabrication, optimization, and characterization of ultra-small superparamagnetic FeO and biocompatible FeO@ZnS core/shell magnetic nanoparticles: Ready for biomedicine applications.超小尺寸超顺磁性 FeO 及生物相容性 FeO@ZnS 核/壳型磁性纳米粒子的制备、优化与性能表征：即将应用于生物医学领域。
Mater Sci Eng C Mater Biol Appl. 2019 May;98:205-212. doi: 10.1016/j.msec.2018.12.147. Epub 2019 Jan 2.
10
Highly water-soluble magnetic iron oxide (FeO) nanoparticles for drug delivery: enhanced in vitro therapeutic efficacy of doxorubicin and MION conjugates.用于药物递送的高水溶性磁性氧化铁（FeO）纳米颗粒：阿霉素与磁性氧化铁纳米颗粒共轭物的体外治疗效果增强
J Mater Chem B. 2013 Jun 14;1(22):2874-2884. doi: 10.1039/c3tb20322k. Epub 2013 May 8.

引用本文的文献

1
Nanodrug Delivery Systems for Acute Lymphoblastic Leukemia Therapy.用于急性淋巴细胞白血病治疗的纳米药物递送系统
Pharmaceuticals (Basel). 2025 Apr 27;18(5):639. doi: 10.3390/ph18050639.
2
Cross-linking of fungal β-glucosidase on AlO nanocrystals synthesized using Cajanus cajan L. Millsp. extracts for in suit genistein manufacture.利用木豆提取物合成的氧化铝纳米晶体上真菌β-葡萄糖苷酶的交联用于原位制造染料木黄酮。
Sci Rep. 2025 Feb 25;15(1):6810. doi: 10.1038/s41598-025-89973-3.
3
Genistein transfersome-embedded topical delivery system for skin melanoma treatment: and evaluations.

本文引用的文献

1
Formulation design facilitates magnetic nanoparticle delivery to diseased cells and tissues.制剂设计有助于将磁性纳米颗粒递送到病变细胞和组织。
Nanomedicine (Lond). 2014 Mar;9(3):469-85. doi: 10.2217/nnm.14.4. Epub 2014 Mar 19.
2
Genistein-inhibited cancer stem cell-like properties and reduced chemoresistance of gastric cancer.染料木黄酮抑制胃癌的癌症干细胞样特性并降低其化疗耐药性。
Int J Mol Sci. 2014 Feb 25;15(3):3432-43. doi: 10.3390/ijms15033432.
3
Use of magnetic folate-dextran-retinoic acid micelles for dual targeting of doxorubicin in breast cancer.
染料木黄酮传递体嵌入型经皮给药系统治疗皮肤黑素瘤的研究：制剂学评价和体内评价。
Drug Deliv. 2024 Dec;31(1):2372277. doi: 10.1080/10717544.2024.2372277. Epub 2024 Jul 1.
4
Recent Advances in Nanobiotechnology for the Treatment of Non-Hodgkin's Lymphoma.纳米生物技术在治疗非霍奇金淋巴瘤中的最新进展。
Mini Rev Med Chem. 2024;24(9):895-907. doi: 10.2174/1389557523666230915103121.
5
Anti-inflammatory and antioxidative effects of genistein in a model of spinal cord injury in rats.染料木黄酮对大鼠脊髓损伤模型的抗炎和抗氧化作用
Asian Biomed (Res Rev News). 2021 Oct 29;15(5):233-243. doi: 10.2478/abm-2021-0029. eCollection 2021 Oct.
6
Application of iron oxide nanoparticles in the diagnosis and treatment of leukemia.氧化铁纳米颗粒在白血病诊断与治疗中的应用。
Front Pharmacol. 2023 Mar 30;14:1177068. doi: 10.3389/fphar.2023.1177068. eCollection 2023.
7
Tumor microenvironment penetrating chitosan nanoparticles for elimination of cancer relapse and minimal residual disease.肿瘤微环境穿透性壳聚糖纳米颗粒用于消除癌症复发和最小残留疾病
Front Oncol. 2022 Nov 30;12:1054029. doi: 10.3389/fonc.2022.1054029. eCollection 2022.
8
Graphene-Based Materials for Efficient Neurogenesis.基于石墨烯的材料促进神经发生。
Adv Exp Med Biol. 2022;1351:43-64. doi: 10.1007/978-981-16-4923-3_3.
9
Chitosan as possible inhibitory agents and delivery systems in leukemia.壳聚糖作为白血病中可能的抑制剂和递送系统。
Cancer Cell Int. 2021 Oct 18;21(1):544. doi: 10.1186/s12935-021-02243-w.
10
Genistein as a regulator of signaling pathways and microRNAs in different types of cancers.染料木黄酮作为不同类型癌症中信号通路和微小RNA的调节剂。
Cancer Cell Int. 2021 Jul 21;21(1):388. doi: 10.1186/s12935-021-02091-8.
磁性叶酸-葡聚糖-视黄酸胶束用于阿霉素在乳腺癌中的双重靶向给药
Biomed Res Int. 2013;2013:680712. doi: 10.1155/2013/680712. Epub 2013 Dec 5.
4
Genistein attenuates cancer stem cell characteristics in gastric cancer through the downregulation of Gli1.金雀异黄素通过下调 Gli1 来减弱胃癌中的癌症干细胞特性。
Oncol Rep. 2014 Feb;31(2):673-8. doi: 10.3892/or.2013.2893. Epub 2013 Dec 2.
5
Preparation and characterization of 6-mercaptopurine-coated magnetite nanoparticles as a drug delivery system.作为药物递送系统的6-巯基嘌呤包覆的磁铁矿纳米颗粒的制备与表征
Drug Des Devel Ther. 2013 Sep 25;7:1015-26. doi: 10.2147/DDDT.S43035. eCollection 2013.
6
Genistein induces G2/M arrest in gastric cancer cells by increasing the tumor suppressor PTEN expression.染料木黄酮通过增加肿瘤抑制因子 PTEN 的表达诱导胃癌细胞 G2/M 期阻滞。
Nutr Cancer. 2013;65(7):1034-41. doi: 10.1080/01635581.2013.810290. Epub 2013 Sep 20.
7
Genistein enhances the efficacy of cabazitaxel chemotherapy in metastatic castration-resistant prostate cancer cells.染料木黄酮增强卡巴他赛化疗治疗转移性去势抵抗性前列腺癌的疗效。
Prostate. 2013 Nov;73(15):1681-9. doi: 10.1002/pros.22705. Epub 2013 Sep 2.
8
Supplementation with fish oil and genistein, individually or in combination, protects bone against the adverse effects of methotrexate chemotherapy in rats.补充鱼油和染料木黄酮，单独或联合使用，可保护大鼠的骨骼免受甲氨蝶呤化疗的不良影响。
PLoS One. 2013 Aug 12;8(8):e71592. doi: 10.1371/journal.pone.0071592. eCollection 2013.
9
Inhibitory effects of a major soy isoflavone, genistein, on human DNA topoisomerase II activity and cancer cell proliferation.染料木黄酮（一种主要的大豆异黄酮）对人源拓扑异构酶 II 活性和癌细胞增殖的抑制作用。
Int J Oncol. 2013 Oct;43(4):1117-24. doi: 10.3892/ijo.2013.2032. Epub 2013 Jul 23.
10
Synthesis, surface modification and characterisation of biocompatible magnetic iron oxide nanoparticles for biomedical applications.用于生物医学应用的生物相容性磁性氧化铁纳米粒子的合成、表面修饰及特性研究。
Molecules. 2013 Jun 27;18(7):7533-48. doi: 10.3390/molecules18077533.