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用于评估血液和血浆中毛细血管波动的光学相干断层扫描技术。

Optical coherence tomography for evaluating capillary waves in blood and plasma.

作者信息

Liu Hsiao-Chuan, Kijanka Piotr, Urban Matthew W

机构信息

Department of Radiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.

Department of Robotics and Mechatronics, AGH University of Science and Technology, Al. Mickiewicza 30, Krakow 30-059, Poland.

出版信息

Biomed Opt Express. 2020 Jan 24;11(2):1092-1106. doi: 10.1364/BOE.382819. eCollection 2020 Feb 1.

Abstract

Capillary waves are associated with fluid mechanical properties. Optical coherence tomography (OCT) has previously been used to determine the viscoelasticity of soft tissues or cornea. Here we report that OCT was able to evaluate phase velocities of capillary waves in fluids. The capillary waves of water, porcine whole blood and plasma on the interfacial surface, air-fluid in this case, are discussed in theory, and phase velocities of capillary waves were estimated by both our OCT experiments and theoretical calculations. Our experiments revealed highly comparable results with theoretical calculations. We concluded that OCT would be a promising tool to evaluate phase velocities of capillary waves in fluids. The methods described in this study could be applied to determine surface tensions and viscosities of fluids for differentiating hematological diseases in the future potential biological applications.

摘要

毛细波与流体力学性质相关。光学相干断层扫描(OCT)此前已被用于确定软组织或角膜的粘弹性。在此我们报告,OCT能够评估流体中毛细波的相速度。本文从理论上讨论了水、猪全血和血浆在界面(此处为气-液界面)上的毛细波,并通过我们的OCT实验和理论计算对毛细波的相速度进行了估计。我们的实验结果与理论计算结果高度可比。我们得出结论,OCT将是评估流体中毛细波相速度的一种很有前景的工具。本研究中描述的方法未来在潜在的生物学应用中可用于确定流体的表面张力和粘度,以鉴别血液疾病。

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