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负载于MIL-100（Cr）金属有机框架上的聚（丙烯酸）/FeO作为一种新型磁性纳米催化剂用于合成吡啶并[2,3-d]嘧啶。

Poly(acrylic acid)/FeO supported on MIL-100(Cr) MOF as a novel and magnetic nanocatalyst for the synthesis of Pyrido[2,3-d]Pyrimidines.

作者信息

Ghasemzadeh Mohammad Ali, Mirhosseini-Eshkevari Boshra

机构信息

Department of Chemistry, Qom Branch, Islamic Azad University, Post Box: 37491-13191, Qom, Iran.

出版信息

Heliyon. 2022 Jul 21;8(8):e10022. doi: 10.1016/j.heliyon.2022.e10022. eCollection 2022 Aug.

DOI:10.1016/j.heliyon.2022.e10022
PMID:36042736
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9420355/
Abstract

In the current work, a convenient and simple approach for preparing poly (acrylic acid)/FeO supported on MIL-100(Cr) for the synthesis of pyrido [2,3-d]pyrimidine derivatives via the three-component one-pot reaction of 1,3-indandione, 6-amino uracil, and aromatic aldehydes is reported. The effectiveness of this new magnetic nanocatalyst was proved. The results showed this nanocatalyst's moderate to high yield under reflux conditions. SEM, TEM, IR, EDX, XRD, BET, and TGA were used to characterize the structure of the synthesized nanocatalyst. This synthetic protocol offers various advantages, including cost-saving, excellent yields in short reaction times (67-98%), low catalyst loading, and catalyst reusability.

摘要

在当前工作中，报道了一种简便的方法来制备负载在MIL-100(Cr)上的聚（丙烯酸）/FeO，用于通过1,3-茚二酮、6-氨基尿嘧啶和芳香醛的三组分一锅法反应合成吡啶并[2,3-d]嘧啶衍生物。证明了这种新型磁性纳米催化剂的有效性。结果表明，该纳米催化剂在回流条件下具有中等到高产率。使用扫描电子显微镜（SEM）、透射电子显微镜（TEM）、红外光谱（IR）、能量散射X射线光谱（EDX）、X射线衍射（XRD）、比表面积分析（BET）和热重分析（TGA）对合成的纳米催化剂的结构进行了表征。该合成方法具有多种优点，包括成本节约、在短反应时间内具有优异产率（67-98%）、低催化剂负载量以及催化剂可重复使用性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e292/9420355/e1acb3a8d736/gr11.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e292/9420355/b167f81853d5/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e292/9420355/a1028f41454c/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e292/9420355/a5236c58f455/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e292/9420355/5e7137f6dd2b/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e292/9420355/82b61caf1588/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e292/9420355/ef60ee5b78f0/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e292/9420355/c1f43cb34158/sc3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e292/9420355/c3bbd6b16304/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e292/9420355/003b8f3edd27/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e292/9420355/644c8b09124e/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e292/9420355/9d4f6492d277/sc4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e292/9420355/e1acb3a8d736/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e292/9420355/1edd59a7306c/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e292/9420355/0cbc02145088/sc2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e292/9420355/0834928b96ef/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e292/9420355/b167f81853d5/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e292/9420355/a1028f41454c/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e292/9420355/a5236c58f455/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e292/9420355/5e7137f6dd2b/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e292/9420355/82b61caf1588/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e292/9420355/ef60ee5b78f0/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e292/9420355/c1f43cb34158/sc3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e292/9420355/c3bbd6b16304/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e292/9420355/003b8f3edd27/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e292/9420355/644c8b09124e/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e292/9420355/9d4f6492d277/sc4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e292/9420355/e1acb3a8d736/gr11.jpg

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