多发性硬化症中血视网膜屏障和血脑屏障变化的频率

Frequency of blood-retina and blood-brain barrier changes in multiple sclerosis.

作者信息

Annunziata P, D'Ettorre M, Menchini U, Moretti L, Guazzi G C

机构信息

Istituto di Scienze Neurologiche, Università di Siena.

出版信息

Ital J Neurol Sci. 1988 Aug;9(4):345-9. doi: 10.1007/BF02333997.

DOI:10.1007/BF02333997

PMID:3220709

Abstract

The frequency of blood-retina barrier (BRB) and blood-brain barrier (BBB) alterations was studied in 20 cases of Multiple Sclerosis (MS) (12 relapsing and 8 chronic-progressive). BBB impairment was found in 7 out of 20 patients (35%), 3 of whom had the chronic-progressive form of the disease. Alterations to BRB were found in 9 out 20 cases (45%): 2 out 12 (17%) of the relapsing cases and 7 out 8 of the chronic-progressive cases (87.5%). BBB impairment was found in 3 of the 9 cases (33%) with BRB alterations. Our findings indicate that BRB and BBB alterations do not occur simultaneously. We propose that the higher frequency of BRB alterations in chronic-progressive MS may be a sign of persistent antigenic stimulation.

摘要

在20例多发性硬化症（MS）患者（12例复发型和8例慢性进展型）中研究了血视网膜屏障（BRB）和血脑屏障（BBB）改变的发生率。20例患者中有7例（35%）存在BBB损伤，其中3例患有慢性进展型疾病。20例中有9例（45%）发现BRB改变：复发型病例中的12例中有2例（17%），慢性进展型病例中的8例中有7例（87.5%）。在9例BRB改变的病例中有3例（33%）发现BBB损伤。我们的研究结果表明，BRB和BBB改变并非同时发生。我们认为，慢性进展型MS中BRB改变的较高发生率可能是持续性抗原刺激的一个迹象。