Engell T, Hvidberg A, Uhrenholdt A
Acta Neurol Scand. 1984 May;69(5):293-7. doi: 10.1111/j.1600-0404.1984.tb07815.x.
Periphlebitis retinae (PR) in multiple sclerosis (MS) is seen as transitory infiltrations around veins in the otherwise normal retina. Cellular infiltrations have been found around veins in the central nervous system (CNS), where it has been suggested that they are the first event in plaque formation. Technetium brain scans are usually normal in MS patients, but transitory abnormal scans of the cerebrum have been found in MS patients during acute attack or exacerbation. In order to test the hypothesis that active PR is a sign of simultaneous disease activity in the CNS, 29 technetium brain scans were carried out on 14 MS patients with active PR and on 15 MS patients without any signs of PR. Significantly more of the patients with active PR, compared with MS patients with previous PR, displayed abnormal brain scans. This indicates that a disruption of the blood brain barrier (BBB) and active PR occur simultaneously in MS.
视网膜静脉周围炎（PR）在多发性硬化症（MS）中表现为在原本正常的视网膜静脉周围的短暂浸润。在中枢神经系统（CNS）的静脉周围已发现细胞浸润，有人认为它们是斑块形成的首个事件。MS患者的锝脑扫描通常正常，但在急性发作或病情加重期间，MS患者的大脑出现过短暂异常扫描。为了检验活动性PR是中枢神经系统同时存在疾病活动迹象这一假说，对14例患有活动性PR的MS患者和15例无PR任何迹象的MS患者进行了29次锝脑扫描。与既往有PR的MS患者相比，活动性PR患者中出现异常脑扫描的比例明显更高。这表明在MS中血脑屏障（BBB）破坏和活动性PR同时发生。
