一种光控适体纳米开关用于时空可控的 siRNA 递送。
A photo-triggerable aptamer nanoswitch for spatiotemporal controllable siRNA delivery.
机构信息
Advanced Research Institute of Multidisciplinary Science; School of Life Science; Institute of Engineering Medicine, Key Laboratory of Molecular Medicine and Biotherapy, Beijing Institute of Technology, Beijing 100081, China.
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190, China.
出版信息
Nanoscale. 2020 May 28;12(20):10939-10943. doi: 10.1039/d0nr00301h.
A photo-triggerable aptamer nanoswitch was proposed for spatiotemporal regulation of siRNA delivery. Recognition between AS1411 and nucleolin was effectively blocked by a photo-labile complementary oligonucleotide, which could be reactivated with photo-irradiation, resulting in efficient tumor-targeted siRNA internalization and gene silencing in vitro and in vivo.
一种光可触发的适体纳米开关被提出用于时空调节 siRNA 的递送。AS1411 和核仁素之间的识别被光不稳定的互补寡核苷酸有效阻断，该寡核苷酸可以通过光照射重新激活，从而导致有效的肿瘤靶向 siRNA 内化和体内外的基因沉默。
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