Center for Molecular Recognition and Biosensing, School of Life Sciences, Shanghai University, Shanghai 200444, P. R. China.
Shanghai Key Laboratory of Bio-Energy Crop, School of Life Sciences, Shanghai University, Shanghai 200444, P. R. China.
Inorg Chem. 2020 Apr 6;59(7):4617-4625. doi: 10.1021/acs.inorgchem.9b03719. Epub 2020 Mar 24.
Porphyrins coordinated with platinum(II) chemotherapeutic drugs are attractive for the development of photosensitizers for photodynamic therapy (PDT) of cancer. In this paper, inorganic and metal-organic nanocomposites were synthesized with cascade-responsive imaging and photochemical synergistic effects. After endo/lysosomal escape, the outer metal-organic frameworks were degraded, leading to the release of an excellent photosensitizer (tetrapyridylporphyrin, PtTPyP). Subsequently, doxorubicin (DOX), inserted in the adenosine triphosphate (ATP) aptamer-functionalized gold nanoparticles, was released under the stimulation of endogenous ATP, synergistically enhancing cancer treatment. Fluorescence imaging allowed tracking of PtTPyP and DOX for real-time detection and on-demand therapy. This strategy endowed the nanocomposites with stability, responsiveness, effectiveness, and ease of synthesis, namely, sTREE strategy. Accordingly, our demonstration provided a promising and smart nanocarrier for imaging and drug delivery.
卟啉与铂（II）化疗药物配位，是开发用于癌症光动力疗法（PDT）的光敏剂的理想选择。本文通过级联响应成像和光化学协同作用合成了无机和金属-有机纳米复合材料。内体/溶酶体逃逸后，外层金属-有机框架被降解，从而释放出一种优异的光敏剂（四吡咯基卟啉，PtTPyP）。随后，插入在三磷酸腺苷（ATP）适体功能化金纳米粒子中的阿霉素（DOX）在内源性 ATP 的刺激下释放，协同增强癌症治疗效果。荧光成像可用于实时检测和按需治疗，追踪 PtTPyP 和 DOX。该策略赋予了纳米复合材料稳定性、响应性、有效性和易于合成的特性，即 sTREE 策略。因此，我们的研究为成像和药物输送提供了一种有前途的智能纳米载体。
