Tan Rongshuang, Wu Jianing, Wang Chunya, Zhao Zhengyan, Zhang Xiaoyuan, Zhong Chang, Tang Zihui, Zheng Rui, Du Binhong, He Yunhan, Sun Yuhua, Zhou Ping
School and Hospital of Stomatology, Key Laboratory of Dental Maxillofacial Reconstruction & Biological Intelligence Manufacturing of Gansu Province, Lanzhou University, Lanzhou, 730000, People's Republic of China.
School of Physical Science and Technology, Lanzhou University, Lanzhou, 730000, People's Republic of China.
J Nanobiotechnology. 2025 Apr 17;23(1):299. doi: 10.1186/s12951-025-03350-w.
The use of fluorescent nanomaterials in tumor imaging and treatment effectively avoids the original limitations of traditional tumor clinical diagnostic methods. The PLNPs emitted persistent luminescence after the end of excitation light. Owing to their superior optical properties, such as a reduced laser irradiation dose, spontaneous fluorescence interference elimination, and near-infrared imaging, PLNPs show great promise in tumor imaging. Moreover, they also achieve excellent anti-tumor therapeutic effects through surface modification and drug delivery. However, their relatively large size and limited surface modification capacity limit their ability to kill tumors effectively enough for clinical applications. Thus, this article reviews the synthesis and modification of PLNPs and the research progress in targeted tumor imaging and tumor killing. We also discuss the challenges and prospects of their future applications in these fields. This review has value for accelerating the design of PLNPs based platform for cancer diagnosis and treatment.
荧光纳米材料在肿瘤成像和治疗中的应用有效避免了传统肿瘤临床诊断方法原有的局限性。激发光结束后，PLNPs发出持续的发光。由于其优异的光学特性，如降低激光照射剂量、消除自发荧光干扰和近红外成像，PLNPs在肿瘤成像中显示出巨大的潜力。此外，它们还通过表面修饰和药物递送实现了优异的抗肿瘤治疗效果。然而，它们相对较大的尺寸和有限的表面修饰能力限制了它们在临床应用中有效杀死肿瘤的能力。因此，本文综述了PLNPs的合成与修饰以及在靶向肿瘤成像和肿瘤杀伤方面的研究进展。我们还讨论了它们在这些领域未来应用的挑战和前景。这篇综述对于加速基于PLNPs的癌症诊断和治疗平台的设计具有价值。
