School of Bioengineering & Key Laboratory of Protein Modification and Disease, Liaoning Province, Dalian University of Technology , Dalian, China.
School of Life Science and Medicine, Dalian University of Technology , Panjin, China.
Immunol Invest. 2021 Feb;50(2-3):184-200. doi: 10.1080/08820139.2020.1718693. Epub 2020 Mar 24.
Tumor necrosis factor superfamily member 4 (TNFSF4) has significant role in modulating autoimmune diseases (ADs) and single nucleotide polymorphism (SNP) is also related with the susceptibility to some diseases. So a meta-analysis aimed at systematically assessing the associations between polymorphisms (rs2205960 G > A, rs704840 T > G and rs844648 G > A) and ADs risk was performed in Asians.
Total 14 eligible articles published before March 2019 involving 35 studies, of which 21 studies (16,109 cases and 26,378 controls) for rs2205960 G > A, 8 studies (2,424 cases and 3,692 controls) for rs704840 T > G, and 6 studies (3,839 cases and 5,867 controls) for rs844648 G > A were included. Effects of the three respective polymorphisms on the susceptibility to ADs were estimated by pooling the odds ratios (ORs) with their corresponding 95% confidence interval (95% CI) in allelic, dominant, recessive, heterozygous and homozygous models.
The overall analysis revealed that all the rs2205960 G > A, rs704840 T > G and rs844648 G > A polymorphisms could increase the risk of ADs in allelic, dominant, recessive, heterozygous and homozygous models. Furthermore, subgroup analysis showed that both rs2205960 G > A and rs704840 T > G were significantly associated with the susceptibility to systemic lupus erythematosus (SLE). What's more, statistically significant association between rs2205960 G > A polymorphism and primary Sjögren's syndrome (pSS) susceptibility was also observed in allelic, dominant and heterozygous models.
This current meta-analysis suggested that all of the three polymorphisms may be associated with ADs susceptibility in Asians.
肿瘤坏死因子超家族成员 4（TNFSF4）在调节自身免疫性疾病（ADs）方面具有重要作用，单核苷酸多态性（SNP）也与某些疾病的易感性有关。因此，进行了一项荟萃分析，旨在系统评估亚洲人群中 TNFSF4 多态性（rs2205960 G > A、rs704840 T > G 和 rs844648 G > A）与 ADs 易感性之间的关系。
共纳入 14 篇符合条件的文献，这些文献发表于 2019 年 3 月之前，包含 35 项研究，其中 rs2205960 G > A 有 21 项研究（16109 例病例和 26378 例对照），rs704840 T > G 有 8 项研究（2424 例病例和 3692 例对照），rs844648 G > A 有 6 项研究（3839 例病例和 5867 例对照）。采用比值比（OR）及其 95%置信区间（95%CI）在等位基因、显性、隐性、杂合子和纯合子模型中评估这三种多态性对 ADs 易感性的影响。
总体分析显示，rs2205960 G > A、rs704840 T > G 和 rs844648 G > A 多态性在等位基因、显性、隐性、杂合子和纯合子模型中均能增加 ADs 的发病风险。此外，亚组分析显示，rs2205960 G > A 和 rs704840 T > G 均与系统性红斑狼疮（SLE）的易感性显著相关。此外，在等位基因、显性和杂合子模型中，rs2205960 G > A 多态性与原发性干燥综合征（pSS）易感性之间也存在统计学显著关联。
本荟萃分析提示，这三种多态性可能与亚洲人群的 ADs 易感性有关。
