College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China.
Key Laboratory of Drug Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu, 610064, China.
Adv Rheumatol. 2021 Sep 19;61(1):59. doi: 10.1186/s42358-021-00215-2.
To more precisely estimate the association between the tumor necrosis factor ligand superfamily member 4 (TNFSF4) gene polymorphisms and systemic lupus erythematosus (SLE) susceptibility, we performed a meta-analysis on the association of the following single nucleotide polymorphisms (SNPs) of TNFSF4 with SLE: rs1234315, rs844648, rs2205960, rs704840, rs844644, rs10489265.
A literature-based search was conducted using PubMed, MEDLINE, Embase, Web of Science databases, and Cochrane Library databases to identify all relevant studies. And the association of TNFSF4 gene polymorphisms and SLE susceptibility was evaluated by pooled odds ratio (OR) with 95% confidence interval (CI).
The meta-analysis produced overall OR of 1.42 (95% CI 1.36-1.49, P < 0.00001), 1.41 (95% CI 1.36-1.46, P < 0.00001) and 1.34 (95% CI 1.26-1.42, P < 0.00001) for the rs2205960, rs1234315 and rs704840 polymorphisms respectively, confirming these three SNPs confer a significant risk for the development of SLE. On the other hand, the meta-analysis produced overall OR of 0.92 (95% CI 0.70-1.21, P = 0.54) for the rs844644 polymorphism, suggesting no significant association. And no association was also found between either rs844648 1.11 (OR 1.11, 95% CI 0.86-1.43, P = 0.41) or rs10489265 (OR 1.17, 95% CI 0.94-1.47, P = 0.17) polymorphism with SLE susceptibility, respectively.
Our meta-analysis demonstrated that the TNFSF4 rs2205960, rs1234315 and rs844840 SNPs was significantly associated with an increased risk of SLE.
更精确地估计肿瘤坏死因子配体超家族成员 4（TNFSF4）基因多态性与系统性红斑狼疮（SLE）易感性之间的关联，我们对以下与 SLE 相关的 TNFSF4 单核苷酸多态性（SNP）进行了荟萃分析：rs1234315、rs844648、rs2205960、rs704840、rs844644、rs10489265。
通过检索 PubMed、MEDLINE、Embase、Web of Science 数据库和 Cochrane 图书馆数据库，基于文献的搜索，以确定所有相关研究。并通过合并比值比（OR）及其 95%置信区间（CI）评估 TNFSF4 基因多态性与 SLE 易感性的关系。
荟萃分析显示，rs2205960、rs1234315 和 rs704840 多态性的总体 OR 分别为 1.42（95%CI 1.36-1.49，P<0.00001）、1.41（95%CI 1.36-1.46，P<0.00001）和 1.34（95%CI 1.26-1.42，P<0.00001），证实这三个 SNP 增加了 SLE 的发病风险。另一方面，荟萃分析显示 rs844644 多态性的总体 OR 为 0.92（95%CI 0.70-1.21，P=0.54），提示无显著相关性。而 rs844648 的 OR 为 1.11（OR 1.11，95%CI 0.86-1.43，P=0.41）或 rs10489265 的 OR 为 1.17（OR 1.17，95%CI 0.94-1.47，P=0.17），这两种多态性与 SLE 易感性之间也没有发现关联。
我们的荟萃分析表明，TNFSF4 rs2205960、rs1234315 和 rs844840 SNP 与 SLE 风险增加显著相关。
