Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei 230032, Anhui, People's Republic of China.
Mod Rheumatol. 2013 Jul;23(4):686-93. doi: 10.1007/s10165-012-0708-8. Epub 2012 Aug 1.
To more precisely estimate the association between the tumor necrosis factor ligand superfamily member 4 (TNFSF4) gene polymorphisms and systemic lupus erythematosus (SLE) risk, we surveyed studies on the association of the TNFSF4 rs2205960, rs1234315, rs844644, and rs844648 polymorphisms with SLE.
A literature-based search was conducted to identify all relevant studies. A total of eight independent studies were identified and subsequently reviewed in the meta-analysis.
The meta-analysis showed an association between the TNFSF4 rs2205960 polymorphism and SLE in all subjects [ odds ratio (OR) 1.327, 95% confidence interval (CI) 1.227-1.436, P < 0.001]. In a subgroup analysis by ethnicity, a significantly increased risk for SLE was associated with TNFSF4 rs2205960 T allele among patients of European (OR 1.254, 95% CI 1.185-1.328, P < 0.001) and Asian ethnicity (OR 1.425, 95% CI 1.352-1.501, P < 0.001). The meta-analysis of the rs1234315 polymorphism revealed no association between SLE and the rs1234315 T allele in all subjects (OR 1.167, 95% CI 0.874-1.558, P = 0.296), but the results of the subgroup analysis revealed significant association in subjects of Asian ethnicity (OR 1.386, 95% CI 1.318-1.458, P < 0.001). No association was found between the rs844644 and rs844648 polymorphisms and SLE.
The results of our meta-analysis suggest that the TNFSF4 rs2205960 polymorphism may confer susceptibility to SLE in different populations and that the TNFSF4 rs1234315 polymorphism is associated with susceptibility to SLE in Asians.
为了更精确地评估肿瘤坏死因子配体超家族成员 4（TNFSF4）基因多态性与系统性红斑狼疮（SLE）风险之间的关联，我们调查了 TNFSF4 rs2205960、rs1234315、rs844644 和 rs844648 多态性与 SLE 关联的研究。
基于文献的搜索，以确定所有相关的研究。共确定了八项独立的研究，并在荟萃分析中进行了综述。
荟萃分析显示，TNFSF4 rs2205960 多态性与所有受试者的 SLE 相关[比值比（OR）1.327，95%置信区间（CI）1.227-1.436，P<0.001]。按种族亚组分析，欧洲（OR 1.254，95%CI 1.185-1.328，P<0.001）和亚洲（OR 1.425，95%CI 1.352-1.501，P<0.001）患者中，TNFSF4 rs2205960 T 等位基因与 SLE 风险显著增加相关。rs1234315 多态性的荟萃分析显示，在所有受试者中，SLE 与 rs1234315 T 等位基因之间无关联（OR 1.167，95%CI 0.874-1.558，P=0.296），但亚组分析结果显示亚洲人群中存在显著关联（OR 1.386，95%CI 1.318-1.458，P<0.001）。rs844644 和 rs844648 多态性与 SLE 无关联。
我们的荟萃分析结果表明，TNFSF4 rs2205960 多态性可能在不同人群中赋予 SLE 易感性，而 TNFSF4 rs1234315 多态性与亚洲人易感性 SLE 相关。
