周细胞在中枢神经系统稳态和疾病中的多方面作用。
Multifaceted roles of pericytes in central nervous system homeostasis and disease.
机构信息
Department of Neurology, Henry Ford Hospital, Detroit, MI, USA.
Department of Physics, Oakland University, Rochester, MI, USA.
出版信息
J Cereb Blood Flow Metab. 2020 Jul;40(7):1381-1401. doi: 10.1177/0271678X20911331. Epub 2020 Mar 24.
Pericytes, the mural cells surrounding microcirculation, are gaining increasing attention for their roles in health and disease of the central nervous system (CNS). As an essential part of the neurovascular unit (NVU), pericytes are actively engaged in interactions with neighboring cells and work in synergy with them to maintain homeostasis of the CNS, such as maintaining the blood-brain barrier (BBB), regulating cerebral blood flow (CBF) and the glymphatic system as well as mediating immune responses. However, the dysfunction of pericytes may contribute to the progression of various pathologies. In this review, we discuss: (1) origin of pericytes and different pericyte markers; (2) interactions of pericytes with endothelial cells (ECs), astrocytes, microglia, oligodendrocytes, and neurons; (3) physiological roles of pericytes in the CNS; (4) effects of pericytes in different CNS diseases; (5) relationship of pericytes with extracellular vesicles (EVs) and microRNAs (miRs); (6) recent advances in pericytes studies and future perspective.
周细胞，即围绕微循环的壁细胞，因其在中枢神经系统（CNS）的健康和疾病中的作用而受到越来越多的关注。作为神经血管单元（NVU）的重要组成部分，周细胞积极参与与邻近细胞的相互作用，并与它们协同工作，以维持 CNS 的内稳态，例如维持血脑屏障（BBB）、调节脑血流量（CBF）和糖质系统以及介导免疫反应。然而，周细胞的功能障碍可能导致各种病理的进展。在这篇综述中，我们讨论了：（1）周细胞的起源和不同的周细胞标志物；（2）周细胞与内皮细胞（ECs）、星形胶质细胞、小胶质细胞、少突胶质细胞和神经元的相互作用；（3）周细胞在 CNS 中的生理作用；（4）周细胞在不同 CNS 疾病中的作用；（5）周细胞与细胞外囊泡（EVs）和 microRNAs（miRs）的关系；（6）周细胞研究的最新进展和未来展望。
Zotero 插件