Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
Beijing Tongren Eye Center, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
Biomed Environ Sci. 2020 Mar 20;33(3):151-157. doi: 10.3967/bes2020.021.
The aim of this study was to investigate macular perfusion changes and ganglion cell complex (GCC) loss in patients with unexplained visual loss following vitrectomy and silicone oil (SO) tamponade, and to evaluate the correlation between retinal blood flow and GCC loss using optical coherence tomography angiography (OCTA) and optical coherence tomography (OCT).
This retrospective study included seven eyes (seven patients) with unexpected visual loss after vitrectomy and SO tamponade. OCTA was used to evaluate the alterations in retinal vessel density (VD) in the superficial capillary plexus (SCP), deep capillary plexus (DCP), and radial peripapillary capillary plexus (RPCP). OCT was used to measure the thickness of GCC and retinal nerve fiber layer (RNFL). Medical records of patients were reviewed.
Quantitative analysis of OCTA images revealed a significant reduction in SCP VD in the affected eyes compared with the controls (all sections < 0.05). No difference was found in GCC thickness, but FLV (focal loss volume) and GLV (global loss volume) were significantly higher in the affected eyes (both < 0.001). SCP VD was inversely correlated with FLV and GLV.
Silicone oil-related severe visual loss was associated with superficial retinal microvasculature damage and ganglion cell apoptosis.
本研究旨在探讨玻璃体切除术后硅油（SO）填充后不明原因视力丧失患者的黄斑灌注变化和节细胞复合体（GCC）损失，并利用光相干断层扫描血管造影（OCTA）和光相干断层扫描（OCT）评估视网膜血流与 GCC 损失之间的相关性。
本回顾性研究纳入了 7 只眼（7 例）在玻璃体切除术后 SO 填充后出现意外视力丧失的患者。OCTA 用于评估浅层毛细血管丛（SCP）、深层毛细血管丛（DCP）和放射状神经纤维层毛细血管丛（RPCP）中视网膜血管密度（VD）的变化。OCT 用于测量 GCC 和视网膜神经纤维层（RNFL）的厚度。回顾患者的病历。
OCTA 图像的定量分析显示，与对照组相比，患眼的 SCP VD 显著降低（所有节段均<0.05）。GCC 厚度无差异，但患眼的 FLV（局灶性丢失体积）和 GLV（全丢失体积）明显更高（均<0.001）。SCP VD 与 FLV 和 GLV 呈负相关。
硅油相关的严重视力丧失与浅层视网膜微血管损伤和节细胞凋亡有关。
