Zhang Bo-Yin, Chang Peng-Yu, Zhu Qing-San, Zhu Yu-Hang
Department of Orthopedic Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China.
Department of Radiotherapy, The First Bethune Hospital of Jilin University, Changchun, Jilin Province, China.
Neural Regen Res. 2020 Sep;15(9):1613-1622. doi: 10.4103/1673-5374.276323.
Spinal cord injury that results in severe neurological disability is often incurable. The poor clinical outcome of spinal cord injury is mainly caused by the failure to reconstruct the injured neural circuits. Several intrinsic and extrinsic determinants contribute to this inability to reconnect. Epigenetic regulation acts as the driving force for multiple pathological and physiological processes in the central nervous system by modulating the expression of certain critical genes. Recent studies have demonstrated that post-SCI alteration of epigenetic landmarks is strongly associated with axon regeneration, glial activation and neurogenesis. These findings not only establish a theoretical foundation for further exploration of spinal cord injury, but also provide new avenues for the clinical treatment of spinal cord injury. This review focuses on the epigenetic regulation in axon regeneration and secondary spinal cord injury. Together, these discoveries are a selection of epigenetic-based prognosis biomarkers and attractive therapeutic targets in the treatment of spinal cord injury.
导致严重神经功能障碍的脊髓损伤通常无法治愈。脊髓损伤临床预后不佳主要是由于受损神经回路无法重建。多种内在和外在因素导致了这种无法重新连接的情况。表观遗传调控通过调节某些关键基因的表达，成为中枢神经系统多种病理和生理过程的驱动力。最近的研究表明，脊髓损伤后表观遗传标志物的改变与轴突再生、胶质细胞激活和神经发生密切相关。这些发现不仅为进一步探索脊髓损伤奠定了理论基础，也为脊髓损伤的临床治疗提供了新途径。本综述聚焦于轴突再生和继发性脊髓损伤中的表观遗传调控。总之，这些发现为脊髓损伤治疗中基于表观遗传学的预后生物标志物和有吸引力的治疗靶点提供了选择。
