Sidorenko G I, Merkurieva R V
Department of Medico-Biological Research, A. N. Sysin Research Institute of General and Communal Hygiene, USSR Academy of Medical Sciences, Moscow.
J Hyg Epidemiol Microbiol Immunol. 1988;32(4):369-74.
The paper theoretically substantiates the importance for detecting the prepathological state of experimental simulation of those situations in the organism which adequately reflect changes in human metabolism exposed to multiple environmental factors. A putative experimental model has been proposed in the shape of sexually immature and mature generations of animals of differing age with a "metabolic burden" whose characteristics, as regards impairments in biochemical, immunological and other functional reactions in biological fluids, are to some extent similar to those occurring in certain groups of humans. It has been suggested that the further investigation of the mechanisms and biological significance of systemic changes of the body's internal milieu may hold promise for studies of environmental hygiene in evaluating populational health and detecting the early signs of metabolic alterations with the aim of their timely prevention.
本文从理论上证实了检测机体实验模拟中的病理前状态的重要性，这些模拟情况能充分反映人类在多种环境因素作用下新陈代谢的变化。已提出一种假定的实验模型，其形式为不同年龄的未成熟和成熟代动物，带有“代谢负担”，就生物体液中生化、免疫和其他功能反应的损伤而言，其特征在一定程度上与某些人类群体中发生的情况相似。有人认为，进一步研究机体内环境系统变化的机制和生物学意义，可能为环境卫生研究带来希望，有助于评估人群健康以及检测代谢改变的早期迹象，以便及时预防。
